{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T21:44:00Z","timestamp":1696887840803},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T00:00:00Z","timestamp":1163030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Allogeneic stem cell transplantation (SCT) is best performed with an HLA\u2010identical sibling donor (matched related donor, MRD) to reduce the risk of early complications such as acute graft\u2010vs.\u2010host disease (aGvHD). However, as only about 30% of recipients have an MRD for this potentially curative approach, the use of family donors with one or two mismatches in the HLA\u2010antigens (mismatch related donor, MMRD) or fully matched unrelated donors (MUD) (\u2018\u2018alternative donors\u2019\u2019) has been introduced in the allogeneic SCT setting in recent years. To evaluate the feasibility of allogeneic SCT from alternative donors by using peripheral blood stem cells (PBSC) we initiated a prospective, phase II study in 1996. From April 1996 to July 1998, 18 patients with various hematological malignancies underwent allogeneic SCT from alternative donors (two patients with MUD and 16 patients with MMRD). All patients received stable engraftment and none of the patients had graft rejection. The rate of aGvHD (grades II\u2013IV) and the relapse rate at last follow\u2010up (seven to nine yr after SCT) were with 40% and 24%, respectively, comparable with those found in patients receiving allogeneic SCT from MRD. However, five yr after allogeneic SCT only 17% were alive, which was mainly due to the treatment\u2010related mortality (TRM) rate of 59%. We conclude that allogeneic PBSC transplantation by using alternative donors is associated with an unsatisfying long\u2010term TRM rate. The significance of TRM and particular late deaths has to be evaluated further in this transplantation setting.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2006.00614.x","type":"journal-article","created":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T17:12:49Z","timestamp":1163092369000},"page":"110-116","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term follow\u2010up of peripheral blood stem cell transplantation from mismatched related and unrelated donors"],"prefix":"10.1111","volume":"21","author":[{"given":"I.W","family":"Blau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Schmidt\u2010Hieber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Basara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Hopfenm\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bischoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"G\u00fcnzelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kirsten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Schmetzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Roemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.G","family":"Kiehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A","family":"Fauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403243301206"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1983.1.9.517"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199510270-00003"},{"key":"e_1_2_5_5_2","first-page":"S34","article-title":"Immunogenetic marrow donor search for 1012 patients: a retrospective analysis of strategies, outcome and costs","volume":"14","author":"Ottinger H","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131301"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197909000-00016"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91793-2"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702168"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01940.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701327"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909163411207"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2866"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.6.1655.bloodjournal8561655"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.6.1666.bloodjournal8561666"},{"key":"e_1_2_5_16_2","first-page":"S40","article-title":"Transplantation of allogeneic peripheral blood progenitor cells \u2013 the EBMT experience","volume":"17","author":"Schmitz N","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_17_2","first-page":"35","article-title":"Allogeneic peripheral blood progenitor cell transplantation: analysis of short\u2010term engraftment and acute GVHD incidence in 33 cases. 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