{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:56:55Z","timestamp":1793887015344,"version":"4.8.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T00:00:00Z","timestamp":1260748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Bryan CF, Luger AM, Smith JL, Warady BA, Wakefield M, Schadde E, Murillo D, Nelson PW. Sharing kidneys across donor\u2010service area boundaries with sensitized candidates can be influenced by HLA C.\u2028Clin Transplant 2010: 24: 56\u201361. \u00a9 2009 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The United Network for Organ Sharing (UNOS) implemented the virtual crossmatch system in UNet as a way to improve the likelihood of a negative crossmatch when kidneys are shared with HLA\u2010sensitized candidates across donor service area (DSA) boundaries. The role of HLA C in that process is not universally appreciated. We recently experienced an unexpected positive flow T and B cell crossmatch for an imported, HLA zero\u2010mismatched kidney because of donor\u2010specific HLA C antibodies and transplanted it into the backup candidate. HLA C locus antigens were not typed by the OPO\u2019s laboratory that sent the kidney so the UNet virtual crossmatch could not \u201cstrike\u201d our candidate from the UNOS match run. HLA C locus typing data of donors for kidneys our DSA imported from other DSAs revealed that C typing was not performed in 23% (14\/60) and was discrepant with our molecular type for 10% (6\/60) and was concordant in 67% (40\/60) of cases. The rate of positive donor\u2010specific crossmatches was higher (83%) for HLA C discrepantly typed donors than for concordantly typed donors (44%). Sensitization for HLA C (42%) is less frequent than for A (80%) or B (83%) locus antigens but the immunogenicity of C locus antigens in patients who make C locus antibodies is equivalent in black and white patients. Finally, the transplant rate of imported kidneys into class I\u2010sensitized candidates was 24%, and C locus\u2010sensitized candidates comprised 55% of those transplanted.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2009.01167.x","type":"journal-article","created":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T11:05:48Z","timestamp":1260788748000},"page":"56-61","source":"Crossref","is-referenced-by-count":19,"title":["Sharing kidneys across donor\u2010service area boundaries with sensitized candidates can be influenced by HLA C"],"prefix":"10.1111","volume":"24","author":[{"given":"Christopher F.","family":"Bryan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Luger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Warady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wakefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Schadde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Murillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01521.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000246311.43634.0a"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000129257.34967.12"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000205202.56915.f5"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000204046.89396.c5"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00746.x"},{"issue":"2","key":"e_1_2_7_8_2","first-page":"235","article-title":"Modeling virtual T and B cell HLA donor specific antibody (DSA) crossmatching with proficiency testing data","volume":"7","author":"Bryan CF","year":"2007","journal-title":"Am J Transplant"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196904032801401"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199203000-00011"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198607000-00022"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4049\/jimmunol.121.2.731","article-title":"Silent alleles at the HLA C locus","volume":"121","author":"Ferrara GB","year":"1978","journal-title":"J Immunol"},{"issue":"2","key":"e_1_2_7_13_2","first-page":"604","article-title":"Limitations of the OPTN\/UNOS CPRA system","volume":"8","author":"Nelson KA","year":"2008","journal-title":"Am J Transplant"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02724.x"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0012.2009.01167.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0012.2009.01167.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T15:16:29Z","timestamp":1698678989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0012.2009.01167.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1111\/j.1399-0012.2009.01167.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0012.2009.01167.x","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}