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Non\u2010invasive assessment of fibrosis in liver grafts due to hepatitis C virus recurrence.\u2028Clin Transplant 2011: 25: 345\u2013351. \u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Hepatitis C virus (HCV) infection has become the most common indication for liver transplantation in the United States and Europe. Recurrence of HCV is universal in all liver graft recipients, but the natural history of the disease is variable with some patients displaying slowly progressive liver injury, while approximately 30% become cirrhotic within five\u2003yr of surgery. Currently, liver biopsy is the reference standard to assess liver injury in the post\u2010transplant setting. But biopsy is associated with complications such as bleeding and pain, as well as the risk of sampling error and discordance in reporting between histopathologists. Thus, as in the pre\u2010transplant setting, there is increasing attention being drawn to the use of non\u2010invasive tests of liver fibrosis. This review examines the role of non\u2010invasive assessment of hepatic fibrosis in the post\u2010transplant setting including simple tests such as aspartate aminotransferase\u2010to\u2010platelet ratio index, the Benlloch formula, London Transplant Centre score, and finally transient elastography. The authors assess the respective advantages and disadvantages of the tests and consider how non\u2010invasive tests of liver fibrosis can be utilized in the future management of post\u2010transplant HCV infection.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2011.01396.x","type":"journal-article","created":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T02:34:27Z","timestamp":1303785267000},"page":"345-351","source":"Crossref","is-referenced-by-count":6,"title":["Non\u2010invasive assessment of fibrosis in liver grafts due to hepatitis C virus recurrence"],"prefix":"10.1111","volume":"25","author":[{"given":"Timothy","family":"J.S. 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