{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:14:44Z","timestamp":1760955284953},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T00:00:00Z","timestamp":1297209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Khandhar SJ, Shah HV, Shullo MA, Zomak R, Navoney M, McNamara DM, Kormos RL, Toyoda Y, Teuteberg JJ. Long\u2010term effects on renal function of dose\u2010reduced calcineurin inhibitor and sirolimus in cardiac transplant patients. \u2028Clin Transplant 2012: 26: 42\u201349. \u2028\u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Calcineurin inhibitor (CNI)\u2010associated renal insufficiency is common after cardiac transplantation (CTX); however, the addition of sirolimus allows for CNI dose reduction and this strategy may limit CNI renal toxicity. This study examines the long\u2010term effects of such a strategy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Patients from a single center who had CTX from 1990 to 2007 and who were converted to sirolimus and a dose\u2010reduced CNI were compared to group\u2010matched controls maintained on CNI and an antiproliferative agent.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> One hundred and fifty\u2010five patients (79 sirolimus and 76 controls) were included and had similar baseline characteristics. Sirolimus was started a mean of 1429\u2003d post\u2010CTX and maintained for a mean of 823\u2003d. Reason for conversion to sirolimus was renal insufficiency (34%), vasculopathy (29%), recurrent rejection (19%), and other (18%). The eGFR was not different between groups at baseline (44.7\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup> vs. 46.0, p\u2003=\u20030.64) or at any point during follow\u2010up: 90\u2003d, 180\u2003d, 1\u2003yr, 2\u2003yr, and 3\u2003yr.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Patients converted to a regimen of sirolimus and a dosed\u2010reduced CNI have stable renal function over the following three\u2003yr, but do not have an improvement in renal outcomes compared to patients maintained on full dose CNI.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2011.01407.x","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T12:17:10Z","timestamp":1297253830000},"page":"42-49","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term effects on renal function of dose\u2010reduced calcineurin inhibitor and sirolimus in cardiac transplant patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Sameer 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