{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:40:10Z","timestamp":1741048810942,"version":"3.38.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T00:00:00Z","timestamp":1299628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>Bj\u00f8rneklett R, Vikse BE, Smerud HK, Bostad L, Leivestad T, Hartmann A, Iversen BM. Pre\u2010transplant course and risk of kidney transplant failure in IgA nephropathy patients.\u2028Clin Transplant 2011: 25: E356\u2013E365. \u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold><jats:bold>Background:\u2002<\/jats:bold>There is lack of knowledge to what degree clinical\/morphological presentation and course of IgA nephropathy (IgAN) prior to end\u2010stage renal disease are risk factors for graft loss after kidney transplantation.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold>Patients with IgAN between 1988 and 2006 (registered in the Norwegian Kidney Biopsy Registry) who later received a kidney transplant (registered in the Norwegian Renal Registry) were included. The cohort was followed up regarding death\u2010censored graft loss throughout 2008. Graft survival with a rapid progressive (RP) vs. a slow progressive (SP) course of pre\u2010Tx IgAN (annual GFR &gt; or &lt;30\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup>) was studied.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Among 106 included patients, there were 14 graft losses giving a graft loss rate of 1.9\/100 patient years. Follow\u2010up until the first kidney transplant was 6.9\u2003\u00b1\u20034.4 (range 0.1\u201319)\u2003yr. Patients with pre\u2010Tx RP had a higher graft loss rate compared with SP patients (6.3 vs.1.3\/100 patient years, p\u2003&lt;\u20030.001). Graft loss rate with living\u2010related donor (LRD) was similar to unrelated donor (UD) grafts. Most RP patients had received LRD grafts, and in SP patients, graft survival with LRD grafts was better than UD grafts (0.3 vs.2.1\/100 patient years, p\u2003=\u20030.055).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>A rapid pre\u2010transplant course is a strong risk factor for transplant failure in patients with IgAN.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2011.01424.x","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T03:38:49Z","timestamp":1299728329000},"source":"Crossref","is-referenced-by-count":7,"title":["Pre\u2010transplant course and risk of kidney transplant failure in IgA nephropathy patients"],"prefix":"10.1111","volume":"25","author":[{"given":"Rune","family":"Bj\u00f8rneklett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn Egil","family":"Vikse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde 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