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Stress and coping in caregivers of patients awaiting solid organ transplantation. \u2028Clin Transplant 2012: 26: 97\u2013104. \u2028\u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Caregivers for patients undergoing solid organ transplantation play an essential role in the process of transplantation. However, little is known about stress and coping among these caregivers. Six hundred and twenty\u2010one primary caregivers of potential candidates for lung (n\u2003=\u2003317), liver (n\u2003=\u2003147), heart (n\u2003=\u2003115), and\/or kidney (n\u2003=\u200342) transplantation completed a psychometric test battery at the time of the candidate\u2019s initial pre\u2010transplant psychosocial evaluation. Caregivers were generally well adjusted, with only 17% exhibiting clinical symptoms of depression (Beck Depression Inventory\u2010II score &gt;13) and 13% reporting clinical levels of anxiety (State Trait Anxiety Inventory score &gt;48). Greater caregiver burden and negative coping styles were associated with higher levels of depression. Greater objective burden and avoidant coping were associated with higher levels of anxiety. 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