{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:56:17Z","timestamp":1787014577527,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"s23","license":[{"start":{"date-parts":[[2011,5,29]],"date-time":"2011-05-29T00:00:00Z","timestamp":1306627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>Takeda A, Ohtsuka Y, Horike K, Inaguma D, Goto N, Watarai Y, Uchida K, Morozumi K. A case of tacrolimus\u2010associated thrombotic microangiopathy after ABO\u2010blood\u2010type\u2010incompatible renal transplantation.\u2028Clin Transplant 2011: 25 (Suppl. 23): 15\u201318.\u2028\u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Abstract:\u2002<\/jats:bold>\n                    De novo thrombotic microangiopathy(TMA) is most commonly triggered by calcineurin inhibitors (CNI) and the prognosis is less severe than with recurrent TMA. However, it is difficult to distinguish de novo TMA from CNI toxicity and acute antibody\u2010mediated rejection(AMR) soon after renal transplantation. We present a case of tacrolimus\u2010associated TMA soon after ABO blood type incompatible renal transplantation that was difficult to differentiate from acute AMR. On day 9 his urine output decreased dramatically and the Scr level increased. His anti\u2010blood type A antibody titer increased to \u00d716 postopratively and the tacrolimus trough level was higher than in our immunosuppressive regimen. Although we gave priority to anti\u2010AMR treatment, adequate dose adjustment of tacrolimus after tacrolimus nephrotoxicity was diagnosed from graft biopsy could correct allograft dysfunction.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-0012.2011.01453.x","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T02:53:52Z","timestamp":1308020032000},"page":"15-18","source":"Crossref","is-referenced-by-count":6,"title":["A case of tacrolimus\u2010associated thrombotic microangiopathy after ABO\u2010blood\u2010type\u2010incompatible renal transplantation"],"prefix":"10.1111","volume":"25","author":[{"given":"Asami","family":"Takeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Ohtsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keij","family":"Horike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizyo","family":"Inaguma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Watarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuharu","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Morozumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,29]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNP67335"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-008-0037-6"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2006.00354.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.17690"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00051.x"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.02.112"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05870710"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03178.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000053402.87256.6B"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0012.2011.01453.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0012.2011.01453.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:12:13Z","timestamp":1694596333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0012.2011.01453.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,29]]},"references-count":9,"journal-issue":{"issue":"s23","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1111\/j.1399-0012.2011.01453.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0012.2011.01453.x","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,29]]}}}