{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:22:06Z","timestamp":1791123726985,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T00:00:00Z","timestamp":1303171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>Snydman DR, Kistler KD, Ulsh P, Bergman GE, Vensak J, Morris J. The impact of CMV prevention on long\u2010term recipient and graft survival in heart transplant recipients: analysis of the Scientific Registry of Transplant Recipients (SRTR) database.\u2028Clin Transplant 2011: 25: E455\u2013E462. \u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The association between cytomegalovirus immunoglobulin (CMVIG) and long\u2010term clinical outcomes in heart transplantation has not been evaluated using data from large national databases. We examined the association between CMVIG, with and without antivirals, or antivirals alone, and long\u2010term recipient and graft survival in heart transplantation using data from the Scientific Registry of Transplant Recipients. Recipients transplanted between January 1995 and October 2008, \u226480\u2003yr old, of primary, single\u2010organ heart transplants, recorded as receiving CMVIG with or without antivirals (n\u2003=\u20032112), antivirals without CMVIG (n\u2003=\u200312 089), or no prophylaxis (n\u2003=\u200314 661), at hospital discharge, were included. Kaplan\u2013Meier analysis was used to examine death and graft loss at seven\u2003yr post\u2010transplantation; Cox proportional hazards regression was used to estimate the adjusted risk of graft loss and death for prophylaxis vs. no prophylaxis. CMVIG use (\u00b1 other antivirals) was associated with increased recipient (69% vs. 64%, p\u2003&lt;\u20030.001) and graft (67% vs. 63%, p\u2003&lt;\u20030.001) survival. Antivirals alone also demonstrated increased recipient (68% vs. 64%, p\u2003&lt;\u20030.001) and graft survival (66% vs. 63%, p\u2003&lt;\u20030.001). Cox models demonstrated that CMVIG (\u00b1 other antivirals) was independently associated with decreased risk for death (hazard ratio, HR 0.79, p\u2003&lt;\u20030.001) and graft loss (HR 0.78, p\u2003&lt;\u20030.001) as were antivirals alone (mortality HR: 0.79, p\u2003&lt;\u20030.001; graft loss: HR 0.78, p\u2003&lt;\u20030.001).<\/jats:p>","DOI":"10.1111\/j.1399-0012.2011.01459.x","type":"journal-article","created":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T11:44:40Z","timestamp":1303299880000},"source":"Crossref","is-referenced-by-count":30,"title":["The impact of CMV prevention on long\u2010term recipient and graft survival in heart transplant recipients: analysis of the Scientific Registry of Transplant Recipients (SRTR) database"],"prefix":"10.1111","volume":"25","author":[{"given":"David R.","family":"Snydman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin 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