{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:45:16Z","timestamp":1697532316300},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T00:00:00Z","timestamp":1323648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Ca\u00f1as L, Bay\u00e9s B, Granada ML, Ibernon M, Porrini E, Ben\u00edtez R, D\u00edaz JM, Lauzurica R, Moreso F, Torres A, Lampreabe I, Serra A, Romero R. Is adiponectin a marker of preclinical atherosclerosis in kidney transplantation? \u2028Clin Transplant 2011 DOI: 10.1111\/j.1399\u20100012.2011.01490.x. \u2028\u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The aim of this study was to analyze the relationship between pre\u2010transplant adiponectin (pre\u2010ADP), abnormalities in glucose homeostasis (AGH) at three\u2003months post\u2010transplantation, and preclinical atherosclerosis in non\u2010diabetic patients prior to kidney transplantation (KT).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We carried out a multicenter study in 157 non\u2010diabetic KT patients (66.5% men; age: 50\u2003\u00b1\u200313\u2003yr). Pre\u2010ADP levels were analyzed using radioimmunoassay. Carotid ultrasound was performed to determine carotid intima\u2010media thickness (c\u2010IMT). Oral glucose tolerance test was carried out to classify patients according ADA criteria.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the patients, 52.8% had AGH. Median pre\u2010ADP was 19.5 (14\u201327) \u03bcg\/mL. An inverse correlation was found between ADP and HOMA index (<jats:italic>r<\/jats:italic>\u2003=\u2003\u22120.432; p\u2003&lt;\u20030.001). Median c\u2010IMT was 0.6 (0.48\u20130.71) mm. Significant inverse correlation existed between ADP and c\u2010IMT on both sides (p\u2003&lt;\u20030.05). Patients with c\u2010IMT &gt;0.6\u2003mm had more AGH (p\u2003=\u20030.012) and lower ADP levels (p\u2003=\u20030.02). We performed a logistic regression analysis using preclinical atherosclerosis (c\u2010IMT \u22650.6\u2003mm) as dependent variable and sex, age, BMI, ADP, AGH, and HOMA index as independent variables of altered c\u2010IMT. Age, pre\u2010ADP, and AGH were independent risk factors for elevated c\u2010IMT.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Patients with AGH have a greater presence of preclinical atherosclerosis. ADP has an inverse relationship with AGH and is an independent marker of preclinical atherosclerosis.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2011.01490.x","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T08:01:37Z","timestamp":1323676897000},"page":"259-266","source":"Crossref","is-referenced-by-count":7,"title":["Is adiponectin a marker of preclinical atherosclerosis in kidney transplantation?"],"prefix":"10.1111","volume":"26","author":[{"given":"Laura","family":"Ca\u00f1as","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Bay\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria 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