{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:59:13Z","timestamp":1771484353753,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T00:00:00Z","timestamp":1316044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Huo M\u2010R, Xu L\u2010P, Li D, Liu D\u2010H, Liu K\u2010Y, Chen H, Han W, Chen Y\u2010H, Wang Y, Wang J\u2010Z, Zhang X\u2010H, Zhao X\u2010Y, Huang X\u2010J. The effect of HLA disparity on clinical outcome after HLA\u2010haploidentical blood and marrow transplantation. \u2028Clin Transplant 2011 DOI: 10.1111\/j.1399\u20100012.2011.01499.x. \u2028\u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The relative importance of various human leukocyte antigen (HLA) loci has not been established for unmanipulated HLA\u2010mismatched\/haploidentical transplantation. To address this question, we analyzed the impact of HLA\u2010A, HLA\u2010B, HLA\u2010DRB1, HLA\u2010DRB3, HLA\u2010DRB4, and HLA\u2010DRB5 on the outcome of HLA\u2010haploidentical transplantation. Four hundred and eighty\u2010one donor\u2013recipient pairs were fully typed before transplantation. In univariate analysis, HLA\u2010B mismatch not only demonstrated significant adverse effects on acute graft\u2010versus\u2010host disease (GVHD) and transplant\u2010related mortality but also was associated with reduced overall survival and leukemia\u2010free survival (LFS). In multivariate analysis, HLA\u2010B mismatch remained the independent risk factor for acute GVHD and transplant\u2010related mortality. The high risk of disease and the female donor were found to be significant factors for reduced overall survival and LFS. Furthermore, multiple mismatch of the HLA locus was found to have no synergistic adverse effect on outcomes. Our results suggest that prospective matching of patients and donors for HLA\u2010B antigen in the unshared HLA haplotype is warranted for HLA\u2010mismatched\/haploidentical transplantation.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2011.01499.x","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T16:42:04Z","timestamp":1316104924000},"page":"284-291","source":"Crossref","is-referenced-by-count":36,"title":["The effect of HLA disparity on clinical outcome after HLA\u2010haploidentical blood and marrow transplantation"],"prefix":"10.1111","volume":"26","author":[{"given":"Ming\u2010Rui","family":"Huo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan\u2010Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"D","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai\u2010Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Y","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang\u2010Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,15]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91793-2"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131301"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810223391702"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.02.007"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890801908903"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705445"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2146"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0691"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0803"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-097386"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.11.4200"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1674"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.11.011"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.10.3515"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704741"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(90)90071-V"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.11.025"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90380-0"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.4.1606.bloodjournal8641606"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2385"},{"key":"e_1_2_8_23_2","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1182\/blood.V74.6.2252.2252","article-title":"Low incidence of acute graft\u2010versus\u2010host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings; possible role of genetic homogeneity. The Nagoya Bone Marrow Transplantation Group","volume":"74","author":"Morishima Y","year":"1989","journal-title":"Blood"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-223172"},{"key":"e_1_2_8_25_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4049\/jimmunol.155.2.585","article-title":"Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft\u2010versus\u2010host disease","volume":"155","author":"Krenger W","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2006.10.002"},{"key":"e_1_2_8_27_2","first-page":"1517","article-title":"In vivo induction of T\u2010cell hyporesponsiveness and alteration of immunological cells of bone marrow grafts using granulocyte colony\u2010stimulating factor","volume":"89","author":"Jun HX","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197905103001902"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198106183042507"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.6.1720.1720"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.3.555.555"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810223391701"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705315"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404566"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0012.2011.01499.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0012.2011.01499.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:44:03Z","timestamp":1697456643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0012.2011.01499.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,15]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1399-0012.2011.01499.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0012.2011.01499.x","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,15]]}}}