{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:07:28Z","timestamp":1761059248782},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T00:00:00Z","timestamp":1318809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Ricart MJ, Oppenheimer F, Andr\u00e9s A, Morales JM, Alonso \u00c1, Fern\u00e1ndez C, on behalf of the Epi\u2010trasplante Study, MIDATA Kidney\u2013Pancreas Sub\u2010study Group. Enteric\u2010coated mycophenolate sodium in <jats:italic>de novo<\/jats:italic> and maintenance kidney\u2013pancreas transplant recipients. \u2028Clin Transplant 2011 DOI: 10.1111\/j.1399\u20100012.2011.01526.x. \u2028\u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold><jats:bold> Background:\u2002<\/jats:bold> Our objective was to describe efficacy and safety of enteric\u2010coated mycophenolate sodium (EC\u2010MPS) in <jats:italic>de novo<\/jats:italic> and maintenance recipients of kidney\u2013pancreas transplant in the clinical practice.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Observational, multicentre, prospective, 12\u2010month study.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We included 24 <jats:italic>de novo<\/jats:italic> and 24 maintenance patients. EC\u2010MPS mean (\u00b1SD) doses at initiation in <jats:italic>de novo<\/jats:italic> patients were 1440\u2003\u00b1\u20030 vs. 1268\u2003\u00b1\u2003263\u2003mg\/d at month 12 (M12). Patient and renal graft survival at one\u2003yr were 100%, and pancreatic graft survival was 83.3% (two losses owing to technical failure and two owing to rejection). In the maintenance cohort, EC\u2010MPS was introduced at a median (P25\u2013P75) of 30 (6\u201371) months after transplant. Baseline doses were 585\u2003\u00b1\u2003310 vs. 704\u2003\u00b1\u2003243\u2003mg\/d at M12. In this group, a significant increase in creatinine clearance was observed (65\u2003\u00b1\u200322 at baseline vs. 74\u2003\u00b1\u200320\u2003mL\/min at M12, p\u2003=\u20030.011). Patient, renal, and pancreatic graft survival were 100%, 95.8%, and 100%, respectively (one kidney graft loss owing to rejection). During follow\u2010up, one patient from each group discontinued EC\u2010MPS.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The efficacy of EC\u2010MPS in the clinical practice of kidney\u2013pancreas transplantation is good, with high patient and grafts survival at 12\u2003months, and good safety profile. The maintenance group displayed an improvement in renal function.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2011.01526.x","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T02:56:09Z","timestamp":1318906569000},"page":"424-431","source":"Crossref","is-referenced-by-count":4,"title":["Enteric\u2010coated mycophenolate sodium in <i>de novo<\/i> and maintenance kidney\u2013pancreas transplant recipients"],"prefix":"10.1111","volume":"26","author":[{"given":"Mar\u00eda J.","family":"Ricart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Oppenheimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amado","family":"Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 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