{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:05:33Z","timestamp":1771002333908,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Srivastava P, Singh A, Kesarwani P, Jaiswal PK, Singh V, Mittal RD. Association studies of Toll\u2010like receptor gene polymorphisms with allograft survival in renal transplant recipients of North India.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Organ transplantation itself inevitably activates the innate immune system by Toll\u2010like receptors (TLRs), potentially leading to allograft rejection and graft failure. We evaluated the possible association of <jats:italic>TLR2, TLR3<\/jats:italic>, and <jats:italic>TLR9<\/jats:italic> polymorphisms of donor\u2010recipient pairs and acute rejection in renal transplant patients of North India. <jats:italic>TLR2<\/jats:italic> (\u2212196 to \u2212174 del), <jats:italic>TLR3<\/jats:italic> (c.1377C\/T; rs 3775290), and <jats:italic>TLR9<\/jats:italic> (+2848\u2003G\/A; rs 352140) were genotyped using DNA samples from 200 donor\u2010recipient pairs of live donor kidney transplantation by applying Restriction Fragment Length Polymorphism (RFLP) methodology. The variant allele frequency of <jats:italic>TLR2<\/jats:italic> (\u2212196 to \u2212174 del) was significantly different between recipients and donors (7.5% vs. 5.0%; p\u2003=\u20030.049; OR\u2003=\u20033.9; 95%CI\u2003=\u20031.01\u201315.32). However, no significant association for allograft rejection was observed in transplant recipients for <jats:italic>TLR3<\/jats:italic> and <jats:italic>TLR9<\/jats:italic>. Interestingly, a low prevalence of AA genotype of <jats:italic>TLR9\u2003+\u20032848\u2003G&gt;A<\/jats:italic> was observed in rejecters when compared with non\u2010rejecters, demonstrating protective association with allograft rejection (OR\u2003=\u20030.30, 95% CI\u2003=\u20030.12\u20130.88, p\u2003=\u20030.028). An allele in patients was also observed to be associated with higher rejection\u2010free survival (log\u2010rank\u2003=\u20030.044). These TLR gene polymorphisms, upon further evaluation, may be helpful in elucidation of immunobiological mechanisms associated with renal graft rejection.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2011.01577.x","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T04:49:20Z","timestamp":1326862160000},"page":"581-588","source":"Crossref","is-referenced-by-count":7,"title":["Association studies of Toll\u2010like receptor gene polymorphisms with allograft survival in renal transplant recipients of North India"],"prefix":"10.1111","volume":"26","author":[{"given":"Priyanka","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anugya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen","family":"Kesarwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen 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