{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:52:09Z","timestamp":1779879129819,"version":"3.53.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T00:00:00Z","timestamp":1331510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Delayed graft function (<jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content>) complicates kidney allograft outcomes in the immediate post\u2010transplantation period. We hypothesized that in hemodialysis patients more severe anemia, iron deficiency, the requirement for higher doses of erythropoietin\u2010stimulating agents (<jats:styled-content style=\"fixed-case\">ESA<\/jats:styled-content>), or blood transfusions prior to transplantation are associated with higher risk of <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Linking five\u2010yr hemodialysis patient data of a large dialysis organization to the Scientific Registry of Transplant Recipients, we identified 11\u00a0836 hemodialysis patients. Using logistic regression analyses we examined the association between pre\u2010transplant parameters and post\u2010transplant <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were 49\u00a0\u00b1\u00a014 (mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) yr old and included 38% women, 27% blacks, and 26% diabetics. After adjusting for relevant covariates, pre\u2010transplant blood transfusion was associated with 33% higher <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content> risk (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]\u00a0=\u00a01.33; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 1.19\u20131.48); and each 5000 <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\/wk increase of pre\u2010transplant ESA dose with 5% higher <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.05; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.02\u20131.09). Compared to pre\u2010transplant blood hemoglobin of 12\u201312.99\u00a0g\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>, there was 25% higher risk of <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content> with blood hemoglobin 10\u201310.99\u00a0g\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.25; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.01\u20131.55), whereas blood hemoglobin \u226513\u00a0g\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> exhibited 15% higher risk of <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.15; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.98\u20131.34).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010transplant blood transfusion, higher <jats:styled-content style=\"fixed-case\">ESA<\/jats:styled-content> dose, and either high or low blood hemoglobin but not iron markers are associated with higher risk of <jats:styled-content style=\"fixed-case\">DGF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-0012.2012.01598.x","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T07:41:30Z","timestamp":1331538090000},"page":"782-791","source":"Crossref","is-referenced-by-count":12,"title":["Associations of pre\u2010transplant anemia management with post\u2010transplant delayed graft function in kidney transplant recipients"],"prefix":"10.1111","volume":"26","author":[{"given":"Miklos Z.","family":"Molnar","sequence":"first","affiliation":[{"name":"Harold Simmons Center for Chronic Disease Research &amp; Epidemiology Los Angeles Biomedical Research Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"},{"name":"Institute of Pathophysiology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba P.","family":"Kovesdy","sequence":"additional","affiliation":[{"name":"Division of Nephrology Salem VA Medical Center Salem VA USA"},{"name":"Division of Nephrology University of Virginia Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Rosivall","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suphamai","family":"Bunnapradist","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Harold Simmons Center for Chronic Disease Research &amp; Epidemiology Los Angeles Biomedical Research Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"},{"name":"Department of Epidemiology UCLA School of Public Health Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elani","family":"Streja","sequence":"additional","affiliation":[{"name":"Harold Simmons Center for Chronic Disease Research &amp; Epidemiology Los Angeles Biomedical Research Institute at Harbor\u2010UCLA Medical Center Torrance CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Krishnan","sequence":"additional","affiliation":[{"name":"DaVita, Inc. 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