{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T01:20:32Z","timestamp":1791768032387,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T00:00:00Z","timestamp":1332201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Abstract<\/jats:title>Prophylactic use of defibrotide (DF<\/jats:styled-content>) to prevent veno\u2010occlusive disease (VOD<\/jats:styled-content>), a relatively common and high\u2010risk complication of hematopoietic stem cell transplantation (HSCT<\/jats:styled-content>), may be an encouraging modality to reduce morbidity and mortality from VOD<\/jats:styled-content>. However, conclusions remain unclear. We carried out a systematic review to summarize the state of knowledge. One randomized controlled trial (RCT<\/jats:styled-content>), four cohort studies and eight case series studies were found, including a total of 1230 patients. The overall mean incidence of VOD<\/jats:styled-content> in patients using DF<\/jats:styled-content> was 4.7% (95% CI<\/jats:styled-content>, 3.3\u20136.1) which was significantly lower than the data 13.7% (95% CI<\/jats:styled-content>, 13.3\u201314.1) across 135 studies using no VOD<\/jats:styled-content> prophylaxis (p\u00a0<\u00a00.005). The meta\u2010analysis of the incidence of VOD<\/jats:styled-content> in controlled trials revealed a statistical reduction in VOD<\/jats:styled-content> incidence in the DF<\/jats:styled-content> group (RR<\/jats:styled-content>\u00a0=\u00a00.47, 95% CI<\/jats:styled-content>, 0.31\u20130.73). The overall mean incidence of severe VOD<\/jats:styled-content> was 0.8% (95% CI<\/jats:styled-content>, 0.2\u20131.4). The RR<\/jats:styled-content> was 0.31 (95% CI<\/jats:styled-content>, 0.09\u20131.06). However, the lack of RCT<\/jats:styled-content>s and the methodological weaknesses of the studies may preclude making generalizable conclusions. Our review described that DF<\/jats:styled-content> appears promising for VOD<\/jats:styled-content> prevention and large RCT<\/jats:styled-content> is needed for further confirmation.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2012.01604.x","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T06:22:37Z","timestamp":1332224557000},"page":"511-519","source":"Crossref","is-referenced-by-count":34,"title":["Defibrotide for the prevention of hepatic veno\u2010occlusive disease after hematopoietic stem cell transplantation: a systematic review"],"prefix":"10.1111","volume":"26","author":[{"given":"Lifei","family":"Zhang","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yebo","family":"Wang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 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