{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:10:51Z","timestamp":1787224251740,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,4]],"date-time":"2012-03-04T00:00:00Z","timestamp":1330819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We postulated that quantitative monitoring of <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>pstein\u2013<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>) shedding after transplantation could distinguish <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010associated illnesses and predict clinical outcome. <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content> was measured in solid organ (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) and hematopoietic cell transplants (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>) using our own real\u2010time <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aq<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>an <jats:styled-content style=\"fixed-case\">EBV PCR<\/jats:styled-content>. The proportion of patients who had <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content>emia post\u2010transplant was significantly lower in <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> (p\u00a0&lt;\u00a00.001). Over a 7.5\u2010yr period, post\u2010transplant lymphoproliferative disorder (<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>) occurred in 66 (5.8%) of 1131 patients who met adequate monitoring criteria. <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients developed <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> significantly later than <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> recipients (median, 2.8\u00a0yr vs. 121\u00a0d; p\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> was documented in 53 (14%) of 376 patients who had <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> in \u22651 whole blood sample vs. 13 (2%) of 755 patients who had at least three <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010negative blood samples and were never positive. <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> risk in viremic patients increased with the peak quantity of <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content>emia (p\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> occurred in 37\/333 (11%) of patients with peak blood levels 10<jats:sup>3<\/jats:sup>\u201310<jats:sup>5<\/jats:sup>\u00a0copies\/mL vs. 16\/43 (37%) of patients with levels &gt;10<jats:sup>5<\/jats:sup> (p\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">EBV PCR<\/jats:styled-content> was predictive in 29 (78%) of 37 patients tested within three\u00a0wk prior to tissue diagnosis of <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>, and thus, we conclude that <jats:styled-content style=\"fixed-case\">EBV PCR<\/jats:styled-content> with careful attention paid to changes in <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content>emia could lead to earlier diagnosis and treatment of <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2012.01608.x","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T21:30:08Z","timestamp":1330983008000},"page":"741-747","source":"Crossref","is-referenced-by-count":58,"title":["Quantitative Epstein\u2013Barr virus shedding and its correlation with the risk of post\u2010transplant lymphoproliferative disorder"],"prefix":"10.1111","volume":"26","author":[{"given":"Carol J.","family":"Holman","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Medical Center Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy B.","family":"Karger","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Medical Center Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth D.","family":"Mullan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Medical Center Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Brundage","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Pharmacology University of Minnesota Medical Center Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Henry H.","family":"Balfour","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Medical Center Minneapolis MN USA"},{"name":"Department of Pediatrics University of Minnesota Medical Center Minneapolis MN 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