{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:43:37Z","timestamp":1791938617282,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"s24","license":[{"start":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T00:00:00Z","timestamp":1340928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Granulomatous interstitial nephritis (<jats:styled-content style=\"fixed-case\">GIN<\/jats:styled-content>) is a rare histologic diagnosis in renal allografts. We report three cases with <jats:styled-content style=\"fixed-case\">GIN<\/jats:styled-content>. Case 1: a 37\u2010yr\u2010old woman received a kidney from her mother. On follow\u2010up 15\u00a0months later, serum creatinine was increased and a graft biopsy showed epithelioid granuloma in the center of massive mononuclear cell infiltration. She had presented with refractory urinary tract infection treated with antibiotics before biopsy. The case was presumed to be <jats:styled-content style=\"fixed-case\">GIN<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content> or hypersensitivity to medication. Case 2: a 47\u2010yr\u2010old woman received a second graft from a non\u2010heart\u2010beating donor. A protocol graft biopsy was performed six\u00a0months after transplantation and showed several granulomatous nodules. She was followed closely without therapy. Case 3: a 27\u2010yr\u2010old woman received an <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible kidney from her father. A protocol graft biopsy was performed three\u00a0months after transplantation and showed granulomatous reaction with severe mononuclear cell infiltration. She received steroid pulse therapy. The two latter patients had no obvious factor contributing to <jats:styled-content style=\"fixed-case\">GIN<\/jats:styled-content>. Therefore, they were presumed to have idiopathic <jats:styled-content style=\"fixed-case\">GIN<\/jats:styled-content>. Infection is considered to be the main causative factor of <jats:styled-content style=\"fixed-case\">GIN<\/jats:styled-content> in renal allografts. This paper describes rare cases of <jats:styled-content style=\"fixed-case\">GIN<\/jats:styled-content> that had no infectious episode in the renal allografts.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2012.01643.x","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T11:36:45Z","timestamp":1340969805000},"page":"70-75","source":"Crossref","is-referenced-by-count":11,"title":["Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature"],"prefix":"10.1111","volume":"26","author":[{"given":"Kiyohiko","family":"Hotta","sequence":"first","affiliation":[{"name":"Departments of Kidney Transplant Surgery Sapporo City General Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Surgical Pathology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Urology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimori","family":"Seki","sequence":"additional","affiliation":[{"name":"Urology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Togashi","sequence":"additional","affiliation":[{"name":"Urology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Departments of Kidney Transplant Surgery Sapporo City General Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,29]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"297","article-title":"Isolated sarcoid granulomatous interstitial nephritis: review of five cases at one center","volume":"55","author":"O'Riordan E","year":"2001","journal-title":"Clin Nephrol"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90300-3"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01790506"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.17735"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.12.050"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/18.2.280"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/5.1.18"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP57142"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199007000-00032"},{"key":"e_1_2_4_11_1","first-page":"1911","article-title":"Tuberculous interstitial granulomatous nephritis in renal transplants: report of three cases","volume":"24","author":"Goncalves AR","year":"1992","journal-title":"Transplant Proc"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50133"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl843"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg511"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2009.01173.x"},{"key":"e_1_2_4_16_1","first-page":"410","article-title":"Isolated sarcoid granulomatous interstitial nephritis in pediatrics: a case report and review of literature","volume":"72","author":"Hobbs DJ","year":"2009","journal-title":"Clin Nephrol"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70083-1"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00299.x"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.10.011"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0012.2012.01643.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0012.2012.01643.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T16:47:00Z","timestamp":1694623620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0012.2012.01643.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,29]]},"references-count":18,"journal-issue":{"issue":"s24","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1399-0012.2012.01643.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0012.2012.01643.x","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,29]]}}}