{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:40:31Z","timestamp":1695508831908},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Work\u2010up of post\u2010transplant lymphoproliferative disorders (<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>s) often involves bone marrow (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>) examinations. We evaluated 23 transplant patients with <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>s to investigate incidence of <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> involvement and associated morphologic changes as well as prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> findings of 23 transplant patients with <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>s who had undergone <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> staging at <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>eoul <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>san <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter from 1994 to 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four (17%) showed <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> involvement of <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>s, including two pathologically diagnosed with <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> by liver and skin biopsy and two diagnosed by <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> examination. <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> subtypes in four patients were all monomorphic, with one each having plasma cell myeloma, diffuse large <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cell lymphoma, monomorphic <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cell lineage, and monomorphic <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lineage. Epstein\u2013<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>) in situ hybridization showed 11 of 23 (47.8%) patients were <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> positive, including two patients with <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> involvement, one each with plasma cell myeloma and monomorphic <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lineage. Epstein\u2013Barr virus infection was observed in nine of 19 patients (39.1%) without <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> involvement or morphologic abnormalities. Mortality rate was higher in patients with than without <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> involvement (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High incidence of <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> involvement in patients with <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> and high mortality rates of these patients suggest <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> examination study may be important in diagnosis and staging work\u2010up of <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-0012.2012.01667.x","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T02:25:14Z","timestamp":1339640714000},"source":"Crossref","is-referenced-by-count":3,"title":["Bone marrow findings of 23 <scp>K<\/scp>orean post\u2010transplant lymphoproliferative disorder patients: a single\u2010center experience"],"prefix":"10.1111","volume":"26","author":[{"given":"Min\u2010Chul","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine University of Ulsan College of Medicine and Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan\u2010Jeoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Ulsan College of Medicine and Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jooryung","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Ulsan College of Medicine and Asan Medical Center  Seoul 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