{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:46:38Z","timestamp":1759333598893},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Within the major histocompatibility complex (MHC), the human leucocyte antigen (HLA)\u2010DRB1 locus is clearly associated with rheumatoid arthritis (RA). Using a microsatellite (MSat) typing approach, we aimed to identify other loci associated with RA susceptibility and\/or severity within the MHC. A panel of nine MSat HLA loci [D6S291, D6S2876 (G51152), D6S1666 (DQCAR II), D6S273, D6S2789 (TNFd), D6S2810 (MIB), D6S265, D6S2222, D6S2239], and HLA\u2010A, \u2010B and \u2010DRB1 genes were typed in 170 RA cases and 282 controls. For susceptibility analysis, MSat and HLA allele distribution were compared between cases and controls, before and after stratification on HLA\u2010DRB1*04. Haplotype frequencies were estimated using an expectation\u2013maximization algorithm in a permutation test procedure. For severity analysis, we compared the distribution of structural damage score at onset and after 4 years of follow\u2010up in RA cases carrying susceptibility alleles. Two MSat polymorphisms were positively associated with RA susceptibility: allele*136 of D6S265 [odds ratio, OR (confidence interval, CI) = 1.55 (1.11\u20132.17), <jats:italic>P<\/jats:italic>= 0.007], allele*116 of D6S2239 [OR = 1.34 (1\u20131.79), <jats:italic>P<\/jats:italic>= 0.03] and HLA\u2010A2 [OR = 1.46 (1.08\u20131.98), <jats:italic>P<\/jats:italic>= 0.01]. Two MSat polymorphisms were negatively associated with RA susceptibility: allele*133 of D6S273 [OR = 0.3 (0.1\u20130.75), <jats:italic>P<\/jats:italic>= 0.005] and allele*177 of D6S291 [OR = 0.72 (0.53\u20130.96), <jats:italic>P<\/jats:italic>= 0.02]. The association between allele*136 of D6S265 and RA susceptibility remained unchanged after stratification on HLA\u2010DRB1*04. The haplotypic analysis showed an overrepresentation of D6S265*136\/HLA\u2010A*02 haplotype, which suggests an effect independent of HLA\u2010DRB1 locus in RA susceptibility. While HLA\u2010A2 and HLA\u2010DR4 were associated with RA severity, no MSat polymorphism was associated with structural damage score.<\/jats:p>","DOI":"10.1111\/j.1399-0039.2006.00693.x","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T08:40:34Z","timestamp":1162888834000},"page":"390-398","source":"Crossref","is-referenced-by-count":6,"title":["Microsatellite typing of the human leucocyte antigen region: analytical approach and contribution to rheumatoid arthritis immunogenetic studies"],"prefix":"10.1111","volume":"68","author":[{"given":"T.","family":"Barnetche","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Constantin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.\u2010A.","family":"Gourraud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Abbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010G.","family":"Garnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cantagrel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cambon\u2010Thomsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/32.10.903"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108382"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.10049"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780301102"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/89.11.821"},{"key":"e_1_2_6_7_2","first-page":"96","article-title":"The influence of the HLA\u2010DRB1 rheumatoid arthritis shared epitope on the clinical characteristics and radiological outcome of psoriatic arthritis","volume":"30","author":"Korendowych E","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364045"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1998)15:4<419::AID-GEPI7>3.0.CO;2-X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370080303"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370100504"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)42:8<1621::AID-ANR9>3.0.CO;2-0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20039"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/422195"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2005.03.015"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.7.830"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2000.550405.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540603.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb03055.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/346067"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6371"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20358"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10719"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2005.00453.x"},{"key":"e_1_2_6_25_2","volume-title":"Proceedings of the 13th International Histocompatibility Workshop and Congress","author":"Hansen JA","year":"2004"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540207.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/302283"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/342407"},{"key":"e_1_2_6_29_2","volume-title":"The Genetics of Disease Susceptibility: Strategies for Analyzing Polygenic HLA Associations Using Microsatellite Markers, chapter 17","author":"Lie BA","year":"2002"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2004.00317.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_32_2","first-page":"15","volume-title":"Standardization of Donor\u2010Recipient Matching in Transplantation. 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