{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:36:05Z","timestamp":1760888165362},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T00:00:00Z","timestamp":1197936000000},"content-version":"vor","delay-in-days":6470,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Microbiology and Immunology"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:p>Neutrophil migration from skin window abrasions was studied in 10 patients with no history of periodontitis, 10 with localised juvenile or post\u2010juvenile periodontitis, and 10 with chronic adult periodontitis. Filters contained either saline or chlorhexidine (0.002% or 0.02%). The leading front was measured in filters placed for 30 min after cell migration had been established for 2 h. Subjects in the juvenile\/post juvenile group showed a reduced range of migration distances, but were still within the normal range when compared with the other 2 groups. Chlorhexidine at 0.002% tended to increase leading front distances, and 0.02% to decrease them. We conclude that: 1) migrating neutrophils <jats:italic>in vivo<\/jats:italic> may move less far in patients with a history of juvenile periodontitis; 2) chlorhexidine may inhibit cell migration, possibly decreasing the host response <jats:italic>in vivo<\/jats:italic> if applied at current therapeutic concentrations.<\/jats:p>","DOI":"10.1111\/j.1399-302x.1990.tb00235.x","type":"journal-article","created":{"date-parts":[[2007,12,19]],"date-time":"2007-12-19T07:58:42Z","timestamp":1198051122000},"page":"95-97","source":"Crossref","is-referenced-by-count":11,"title":["An <i>in vivo<\/i> study of neutrophil locomotion in relation to periodontal disease status and local chlorhexidine"],"prefix":"10.1111","volume":"5","author":[{"given":"Kevin G.","family":"Seymour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor L. 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