{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:32:01Z","timestamp":1789813921776,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T00:00:00Z","timestamp":1156118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Microbiology and Immunology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background\/aims:\u2002<\/jats:bold> The immunoglobulin G (IgG) antibody response is considered to be protective and beneficial for the control of periodontal lesions. This study analysed IgG subclass antibody levels of <jats:italic>Porphyromonas gingivalis<\/jats:italic> in patients with both aggressive periodontitis (AgP) and chronic periodontitis (CP).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Subgingival plaque and peripheral blood samples were collected from patients with localized AgP (<jats:italic>n<\/jats:italic>\u2003=\u200313), generalized AgP (<jats:italic>n<\/jats:italic>\u2003=\u200328) and generalized CP (<jats:italic>n<\/jats:italic>\u2003=\u200327) and from 14 periodontally healthy controls. <jats:italic>P. gingivalis<\/jats:italic> was identified in subgingival pockets using a polymerase chain reaction. Simultaneously, serum IgG subclass antibody against <jats:italic>P. gingivalis<\/jats:italic> whole cells\/<jats:italic>P. gingivalis<\/jats:italic> fimbriae were measured using enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:italic>P. gingivalis<\/jats:italic> was frequently detected in periodontitis patients. Anti\u2010<jats:italic>P. gingivalis<\/jats:italic> whole cell IgG1 was elevated in all <jats:italic>P. gingivalis\u2010<\/jats:italic>positive patients in the three periodontitis groups. Although increased anti\u2010<jats:italic>P. gingivalis<\/jats:italic> IgG1 was also observed in the bacterium\u2010positive healthy controls, the level was lower than that found in the three periodontitis groups. Levels of IgG1, IgG2, IgG3 and IgG4 to <jats:italic>P. gingivalis<\/jats:italic> did not differ among bacterium\u2010positive patients in the three periodontitis groups; a significant increase of IgG2 level was not observed in localized AgP. Anti\u2010fimbriae IgG subclass levels of IgG1, IgG2 and IgG4 did not differ among bacterium\u2010positive subjects in all groups, while the anti\u2010fimbriae IgG3 level in generalized CP was significantly higher than that in localized and generalized AgP.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:italic>P. gingivalis<\/jats:italic> infection elicited an IgG subclass antibody response in both periodontitis patients and healthy subjects, while higher anti\u2010<jats:italic>P. gingivalis<\/jats:italic> IgG1 levels were found in the three periodontitis groups compared with the healthy control group.<\/jats:p>","DOI":"10.1111\/j.1399-302x.2006.00296.x","type":"journal-article","created":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T07:45:28Z","timestamp":1156146328000},"page":"314-318","source":"Crossref","is-referenced-by-count":24,"title":["Immunoglobulin G subclass antibody profiles in <i>Porphyromonas gingivalis<\/i>\u2010associated aggressive and chronic periodontitis patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Y.","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Aramaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Umeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4049\/jimmunol.130.2.722","article-title":"Serologic aspects of IgG4 antibodies. 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