{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:22:57Z","timestamp":1762100577670},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T00:00:00Z","timestamp":1161648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Microbiology and Immunology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Periodontitis is a chronic inflammatory disease that results in extensive soft and hard tissue destruction of the periodontium. <jats:italic>Porphyromonas gingivalis<\/jats:italic> possesses an array of virulence factors and has been shown to induce expression of inducible nitric oxide synthase (iNOS) in inflammatory cells. The aim of this study was to investigate the effect of eliminating iNOS in a murine model of <jats:italic>P. gingivalis<\/jats:italic> infection. This was achieved by utilizing a <jats:italic>P. gingivalis<\/jats:italic>\u2010induced skin abscess model, and an alveolar bone loss model employing an oral infection of <jats:italic>P. gingivalis<\/jats:italic> in iNOS knockout mice. The results indicated that iNOS knockout mice exhibit more extensive soft tissue damage and alveolar bone loss in response to <jats:italic>P. gingivalis<\/jats:italic> infection compared to wild\u2010type mice. The local immune response to <jats:italic>P. gingivalis<\/jats:italic> in iNOS knockout mice was characterized by increased numbers of polymorphonuclear monocytes, while the systemic immune response was characterized by high levels of interleukin\u201012. The iNOS is required for an appropriate response to <jats:italic>P. gingivalis<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/j.1399-302x.2006.00304.x","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T16:11:46Z","timestamp":1161706306000},"page":"360-365","source":"Crossref","is-referenced-by-count":31,"title":["Deficiency of iNOS contributes to <i>Porphyromonas gingivalis<\/i>\u2010induced tissue damage"],"prefix":"10.1111","volume":"21","author":[{"given":"J.","family":"Alayan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ivanovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Gemmell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hamlet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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