{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T15:57:50Z","timestamp":1794067070170,"version":"4.8.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,13]],"date-time":"2006-04-13T00:00:00Z","timestamp":1144886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>Although <jats:italic>Mycoplasma pneumoniae<\/jats:italic> infection is known to be associated with acute wheezing and the exacerbation of asthma, the mechanism by which this pathogen contributes to the development of wheeze\u2010related symptoms is not fully understood. The aim of our study was to examine serum endothelin (ET)\u20101 and other cytokines in acute <jats:italic>M. pneumoniae<\/jats:italic> pneumonia and investigate if there is any relation between these inflammatory mediators and the occurrence of wheezing. We studied 53 patients, aged 3\u201313\u2003yr, who admitted with pneumonia. These patients were divided into three groups: <jats:italic>M. pneumoniae<\/jats:italic> pneumonia with wheeze (n\u2003=\u200323) and without wheeze (n\u2003=\u200319), and the patients without the evidence of <jats:italic>M. pneumoniae<\/jats:italic> infection (n\u2003=\u200311). Age\u2010matched controls (n\u2003=\u200310) were also studied. The serum concentrations of ET\u20101, interleukin (IL)\u20105 and IL\u201018 were measured using ELISA kits in patient groups and controls. The patients with <jats:italic>M. pneumoniae<\/jats:italic> pneumonia had significantly higher serum ET\u20101 than those without evidence of <jats:italic>M. pneumoniae<\/jats:italic> infection. In the presence of <jats:italic>M. pneumoniae<\/jats:italic> pneumonia, ET\u20101 concentrations were significantly higher in the patients with wheeze than those without wheeze. IL\u20105 and IL\u201018 in each patient group were higher compared to controls. However, no significant between\u2010group difference was observed. Total serum IgE levels were significantly higher in the patients with <jats:italic>M. pneumoniae<\/jats:italic> pneumonia and wheeze than in those without wheeze. A positive correlation was observed between serum ET\u20101 and total IgE in the patients with <jats:italic>M. pneumoniae<\/jats:italic> pneumonia and wheeze. Our results may suggest a role of ET\u20101 in the occurrence of acute wheezing or exacerbation of asthma associated with <jats:italic>M. pneumoniae<\/jats:italic> pneumonia.<\/jats:p>","DOI":"10.1111\/j.1399-3038.2006.00393.x","type":"journal-article","created":{"date-parts":[[2006,4,23]],"date-time":"2006-04-23T15:50:20Z","timestamp":1145807420000},"page":"285-290","source":"Crossref","is-referenced-by-count":13,"title":["The relationship between serum endothelin (ET)\u20101 and wheezing status in the children with <i>Mycoplasma pneumoniae<\/i> pneumonia"],"prefix":"10.1111","volume":"17","author":[{"given":"Hai Lee","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Im 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