{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:21:21Z","timestamp":1791397281440,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T00:00:00Z","timestamp":1146614400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>To assess the regulatory changes of immune system in children genetically pre\u2010disposed to allergic diseases and in their mothers, we tested cytokines IL\u20104, IL\u20105, IL\u20106, IL\u201010, IL\u201013, IFN\u2010<jats:italic>\u03b3<\/jats:italic> and TGF\u2010<jats:italic>\u03b2<\/jats:italic> in 21 healthy and 21 allergic mothers (serum at the time of delivery, colostrum and milk throughout the suckling period) and their children (cord blood, venous blood and stool filtrates) up to 1\u2003yr of age. Samples were taken at the time of delivery, 4\u2003days post\u2010partum and then after 3, 6 and 12\u2003months. Significant differences between the healthy and the allergic group were found in the levels of IL\u20104, IL\u201010, IL\u201013 and IFN\u2010<jats:italic>\u03b3<\/jats:italic>. The levels of IL\u20104 in the allergic group were generally higher; the levels in the sera of children of allergic mothers during the post\u2010natal life decreased, reaching levels typical for the healthy group at 1\u2003yr of age. Allergic mothers exhibited markedly higher IL\u201010 levels in the serum at the time of delivery and in milk 3\u2003months after delivery than healthy mothers while after 6\u2003months the IL\u201010 levels in all samples from the allergic group were very low. Children from allergic group had lower intestinal content of IL\u201013 in comparison with the healthy counterparts. At 1\u2003yr of age, the levels of IFN\u2010<jats:italic>\u03b3<\/jats:italic> in sera and stool of children from the allergic group sharply increased. TGF\u2010<jats:italic>\u03b2<\/jats:italic> levels in the sera of both groups were high, while in the milk they were relatively low and substantially lower that in the children's stool. TGF\u2010<jats:italic>\u03b2<\/jats:italic> of mammary secretions is therefore unlikely to exert a decisive regulatory influence on the children's immunity. Long\u2010term clinical monitoring of the children will be performed to evaluate the potential prognostic significance of these changes for the future development of allergies.<\/jats:p>","DOI":"10.1111\/j.1399-3038.2006.00395.x","type":"journal-article","created":{"date-parts":[[2010,9,20]],"date-time":"2010-09-20T15:08:32Z","timestamp":1284995312000},"page":"175-183","source":"Crossref","is-referenced-by-count":48,"title":["Cytokine levels in healthy and allergic mothers and their children during the first year of life"],"prefix":"10.1111","volume":"17","author":[{"given":"Ludmila","family":"Proke\u0161ov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Lodinov\u00e1\u2010\u017d\u00e1dn\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"\u017di\u017eka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Kocourkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Novotn\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Petr\u00e1skov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"\u0160terzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01646.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-005-0248-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.12.003"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00765.x"},{"key":"e_1_2_6_6_2","first-page":"1501","volume-title":"Mucosal Immunology","author":"Hanson LA","year":"1998"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb06049.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.04.028"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2003.02119.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh208"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200011000-00014"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200001000-00026"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00338-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000055778.58807.C8"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2004.00143.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70021-7"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70094-1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14542-4"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200005000-00006"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb06004.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2000.00882.x"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3038.2006.00395.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3038.2006.00395.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:38:46Z","timestamp":1696894726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3038.2006.00395.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1399-3038.2006.00395.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3038.2006.00395.x","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}