{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:22:19Z","timestamp":1778289739613,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T00:00:00Z","timestamp":1149552000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>Although cysteinyl\u2010leukotriene receptor antagonists were recently approved for use in allergic rhinitis (AR), there has been no study to date investigating their application in children. The aim was to evaluate whether montelukast provides any benefit in nasal allergen challenge\u2010induced symptoms in children, and whether it could improve the control provided by an antihistamine during pollen season. Two randomized studies, one a double\u2010blind, placebo\u2010controlled, nasal allergen challenge study and one an open\u2010label, cross\u2010over, parallel\u2010group clinical study, were performed in 18 (11.7\u2003\u00b1\u20030.7\u2003years) and 32 children (10.5\u2003\u00b1\u20030.5\u2003years), respectively, with grass pollen allergy. In the first study, the effect of a single dose of montelukast and its combination with loratadine were compared with placebo on nasal responses induced by allergen challenge. In the second study, the additive effect of montelukast to loratadine was tested in an open\u2010label cross\u2010over clinical study. In the challenge study, early\u2010phase and late\u2010phase nasal reactions peaked at 15\u2003min and 4\u2003h after the challenge respectively. During the early phase, combination improved total nasal symptoms (p\u2003=\u20030.004) during the first hour and sneezing (p\u2003=\u20030.012) at 15\u2003min compared with placebo group. During the late phase, montelukast (p\u2003=\u20030.017) and combination (p\u2003=\u20030.011) caused less nasal obstruction at 4\u2003h and combination caused less sneezing at 6\u2003h (p\u2003=\u20030.015). In the clinical trial, montelukast provided protection on seasonal increase in pulmonary symptoms [0 (0, 14) vs. 6.5 (0, 27.7); p\u2003=\u20030.016] and on the decrease in FEF<jats:sub>25\u221275<\/jats:sub> [\u22120.09 (\u22120.34, 0.17) vs. \u22120.28 (\u22120.66, 0.02); p\u2003=\u20030.002]. However, there was no improvement in nasal symptoms and flows. Although we showed protection against nasal challenge\u2010induced congestion with montelukast, we were not able to show the same in the clinical study possibly because of low pollen counts and mildness of the symptoms of the patients with AR. However, montelukast provided better control of pulmonary symptoms and protection from seasonal decrease in lung function, indicating its potential therapeutic benefit in children with AR.<\/jats:p>","DOI":"10.1111\/j.1399-3038.2006.00397.x","type":"journal-article","created":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T10:16:06Z","timestamp":1149588966000},"page":"259-268","source":"Crossref","is-referenced-by-count":23,"title":["Do the leukotriene receptor antagonists work in children with grass pollen\u2010induced allergic rhinitis?"],"prefix":"10.1111","volume":"17","author":[{"given":"Ozlem","family":"Keskin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evrim","family":"Alyamac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayfer","family":"Tuncer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cahit","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonul","family":"Adalioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent Enis","family":"Sekerel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00005.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.5.1533"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109193251206"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-26"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01422.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61891-1"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2001.00964.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00261.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62144-8"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.106040"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62250-8"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00651.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01145.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00802.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198406213102502"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113188"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1985.tb04147.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.2.357"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90076-6"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198507113130201"},{"key":"e_1_2_7_22_2","first-page":"537","article-title":"The role of leukotriene D4 in allergic rhinitis","volume":"60","author":"Okuda M","year":"1988","journal-title":"Ann Allergy"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1986.tb01960.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010200303"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012203232506"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237065"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62138-2"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.1.112"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113188"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90460-J"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/288484a0"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608213150803"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91073-U"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61409-3"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00261102"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110670"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3038.2006.00397.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3038.2006.00397.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:46:31Z","timestamp":1696895191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3038.2006.00397.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1399-3038.2006.00397.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3038.2006.00397.x","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}