{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:46:43Z","timestamp":1759729603590},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>Several studies have suggested that respiratory syncytial virus (RSV) bronchiolitis induced the change of cytokine production profile in childhood. We sought to determine whether the RSV\u2010induced cytokine production was affected by the patient's atopic background. We quantified interferon\u2010gamma (IFN\u2010gamma) and interleukin (IL)\u20104 in the supernatant of peripheral blood mononuclear cells (PBMCs) cultured for 24\u2003h and in the presence of phytohemaglutinin (PHA), IL\u201012, or IL\u201018, from 14 infants who were divided into two groups, those who are non\u2010atopic and an atopic group. In RSV\u2010infected infants with atopic diseases, IFN\u2010gamma production from IL\u201012\u2010 or especially IL\u201018\u2010stimulated PBMCs was subtotally suppressed in the acute phase, whereas in RSV\u2010infected infants without atopic diseases IFN\u2010gamma production was not suppressed on acute phase. The IFN\u2010gamma suppression observed in the atopic group is not caused by the immaturity of an infant's immune system since reduced IFN\u2010gamma production to RSV is not observed in the infants of non\u2010atopic group. IFN\u2010gamma suppression in regard to RSV infection might be caused by some genetic factor involved in the development of atopic disease such as IL\u201018 signal cascade.<\/jats:p>","DOI":"10.1111\/j.1399-3038.2006.00419.x","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T18:25:42Z","timestamp":1152210342000},"page":"370-375","source":"Crossref","is-referenced-by-count":8,"title":["Suppression of IFN\u2010gamma production in atopic group at the acute phase of RSV 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