{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:18:49Z","timestamp":1790918329514,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,9,4]],"date-time":"2006-09-04T00:00:00Z","timestamp":1157328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Longitudinal studies in infant populations using validated diagnostic criteria of atopic dermatitis and sensitization are rarely reported, and disease definitions, testing procedures, age of study population and evaluation of objective markers vary between countries and studies. The objectives of this prospective birth cohort study were to investigate: (i) the prevalence, the cumulative incidence and the pattern of transient and persistent sensitization to common food\u2010 and aeroallergens in unselected infants, (ii) the association between sensitization and the development of atopic dermatitis (AD) and (iii) the association between selected perinatal risk factors with respect to AD and post\u2010natal sensitization. During a one\u2010year period a cohort of 562 unselected newborns was established and followed up at the age of 3, 6, 9, 12 and 18\u2003months of age. At all time points infants were examined clinically and by histamine release (HR), total\u2010 and specific immunoglobulin E (IgE) and skin prick test (SPT). Sensitization ever to \u22651 allergen at 18\u2003months of age was 59%, 50% and 6% using HR, IgE and SPT, respectively. A transient sensitization to \u22651 allergen was found in 47%, 42% and 4% and a persistent sensitization in 17%, 10% and 3%, respectively. Sensitization to environmental allergens was frequently observed in infancy when testing with HR and IgE. Results of SPT gave much lower frequencies. Reactivity to foods was more frequent than to aeroallergens. The dominant pattern was low\u2010level transient sensitization. This is important to know when sensitization tests are used in the course of examination of infants with eczematous skin diseases. Specific definitions of sensitization like persistent reactivity, high\u2010level sensitization and poly sensitization were clearly associated with AD. A maternal history of AD was a valuable tool in predicting AD in early infancy; a similar finding was less obvious with regard to post\u2010natal sensitization. Cord\u2010specific IgE and cord\u2010HR positive reactivity did not prove better tools than cord\u2010total IgE in predicting AD within the first 18 living months.<\/jats:p>","DOI":"10.1111\/j.1399-3038.2006.00453.x","type":"journal-article","created":{"date-parts":[[2006,9,4]],"date-time":"2006-09-04T16:25:15Z","timestamp":1157387115000},"page":"591-600","source":"Crossref","is-referenced-by-count":62,"title":["Patterns of sensitization in infants and its relation to atopic dermatitis"],"prefix":"10.1111","volume":"17","author":[{"given":"Hanne","family":"J\u00f8hnke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene Annette","family":"Norberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Vach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"H\u00f8st","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Ejner","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2001.00002.x-i1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00109.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1993.tb03238.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1224.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00115.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1997.310899.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118786"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.591"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_2_6_11_2","first-page":"116","article-title":"Epidemiology of atopic dermatitis","volume":"21","author":"Hanifin JM","year":"1987","journal-title":"Monogr Allergy"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06491.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1987.tb02223.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1994.tb00343.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1993.tb00089.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1984.tb02243.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05987.x"},{"key":"e_1_2_6_18_2","unstructured":"JohnkeH.Environmental factors and atopic predisposition as predictors for the development of atopic eczema in childhood.PhD thesis. 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