{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:14:47Z","timestamp":1790399687282,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,9,4]],"date-time":"2006-09-04T00:00:00Z","timestamp":1157328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Inhaled beclomethasone dipropionate (BDP) with the propellant hydrofluroroalkane\u2010134a (HFA) has been designed to be equivalent in terms of safety to chlorofluorocarbon (CFC)\u2010formulated metered dose inhalers (MDI). The aim was to assess whether BDP HFA MDI 100\u2003<jats:italic>\u03bc<\/jats:italic>g twice daily was equivalent to BDP CFC MDI 100\u2003<jats:italic>\u03bc<\/jats:italic>g twice daily in terms of effects on short\u2010term lower leg growth rate (LLGR) and measures of hypothalamic\u2013pituitary\u2013adrenal (HPA) function. The study consisted of a randomized double\u2010blind cross\u2010over trial with three active, a run\u2010in and two wash\u2010out periods each consisting of 2\u2003wk. <jats:italic>The place of study was<\/jats:italic> a secondary referral outpatient clinic. The subjects involved were 14 boys and 10 girls with asthma, aged 7\u201312\u2003yr. They were all administered BDP HFA 100\u2003<jats:italic>\u03bc<\/jats:italic>g, BDP CFC 100\u2003<jats:italic>\u03bc<\/jats:italic>g and 200\u2003<jats:italic>\u03bc<\/jats:italic>g twice daily. The outcome measures included LLGR and 24\u2010h urine\u2010free cortisol (UFC) and total cortisol metabolites (TCM). Mean (SD) LLGR during run\u2010in and BDP HFA 100\u2003<jats:italic>\u03bc<\/jats:italic>g, BDP CFC 100\u2003<jats:italic>\u03bc<\/jats:italic>g and 200\u2003<jats:italic>\u03bc<\/jats:italic>g twice daily periods were 0.43 (0.23), 0.09 (0.29), 0.10 (0.45) and 0.08 (0.27) mm\/wk. The one\u2010sided 97.5% confidence interval for the difference in LLGR between BDP HFA 100\u2003<jats:italic>\u03bc<\/jats:italic>g and BDP CFC 100\u2003<jats:italic>\u03bc<\/jats:italic>g was 0.24, thus, below the predefined criterion of 0.20\u2003mm\/week. Inter\u2010period comparisons of active treatments showed no differences between means of LLGR, UFC or TCM. Though non\u2010inferiority between BDP HFA and CFC 100\u2003<jats:italic>\u03bc<\/jats:italic>g twice daily in terms of effects on LLGR was not found, equivalence was suggested by comparisons of LLGR during run\u2010in and active treatments and by HPA function measures.<\/jats:p>","DOI":"10.1111\/j.1399-3038.2006.00460.x","type":"journal-article","created":{"date-parts":[[2006,9,4]],"date-time":"2006-09-04T16:25:15Z","timestamp":1157387115000},"page":"613-619","source":"Crossref","is-referenced-by-count":15,"title":["Short\u2010term growth and adrenal function in children with asthma treated with inhaled beclomethasone dipropionate hydroflouroalkane\u2010134a"],"prefix":"10.1111","volume":"17","author":[{"given":"O. D.","family":"Wolthers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00137-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(02)80019-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2003.10.001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/08831870260093852"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1191\/0962280203sm314ra"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.5.673"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(97)00053-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70098-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02986.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/03014469700005302"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/03014469700005172"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00648-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020287"},{"key":"e_1_2_6_15_2","first-page":"411","article-title":"Knemometry in children with atopic dermatitis treated with topical glucocorticoids","volume":"24","author":"Heuck C","year":"1997","journal-title":"Pediatr Dermatol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088348"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/03014468800009411"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000023127"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2003.16.7.973"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770909909054553"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10071507"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6795.163"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3038.2006.00460.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3038.2006.00460.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T04:53:34Z","timestamp":1697259214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3038.2006.00460.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,4]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1399-3038.2006.00460.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3038.2006.00460.x","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,4]]}}}