{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:58:21Z","timestamp":1792792701000,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T00:00:00Z","timestamp":1169078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>There have been longitudinal studies of the developmental change of the immune system during the first year of life. The aim of this study was to investigate if there is any age\u2010related difference in cytokine responses to respiratory syncytial virus (RSV) infection between the patients under 6\u2003months of age and the patients over 12\u2003months of age compared with age\u2010matched controls. Forty\u2010five children \u226424\u2003months of age who were admitted with acute RSV bronchiolitis were enrolled. The patients were divided into two groups: the infants \u22646\u2003months old and the young children \u226512\u2003months old. Immune response to RSV infection was determined by measuring the serum concentrations of cytokines and compared with age\u2010matched controls. Serum samples were obtained on admission and analyzed for interferon (IFN)\u2010<jats:italic>\u03b3<\/jats:italic>, interleukins (IL)\u201010, \u201013, and \u20104 using ELISA. Comparing the cytokine levels of two control groups, both IFN\u2010<jats:italic>\u03b3<\/jats:italic> and IL\u201013 were lower in the children \u226512\u2003months of age than in the infants \u22646\u2003months of age. IL\u201010 and IL\u20104 showed no significant changes with age. Comparing with age\u2010matched controls, IFN\u2010<jats:italic>\u03b3<\/jats:italic> levels were significantly higher in RSV group \u226512\u2003months of age, but showed a tendency toward lower levels in RSV group \u22646\u2003months of age. Both IL\u201010 and IL\u201013 levels were significantly higher in RSV group \u226512\u2003months of age, but showed no significant difference in RSV group \u22646\u2003months of age. Our study demonstrated a significant age\u2010related difference in immune response to RSV infection during early life. It suggests that the developmental changes in cytokine responses to RSV infection may be considered in the control of RSV bronchiolitis in young children.<\/jats:p>","DOI":"10.1111\/j.1399-3038.2006.00501.x","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T12:52:07Z","timestamp":1172667127000},"page":"94-99","source":"Crossref","is-referenced-by-count":27,"title":["Age\u2010related difference in immune responses to respiratory syncytial virus infection in young children"],"prefix":"10.1111","volume":"18","author":[{"given":"Hai Lee","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0059"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00508-0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.110531"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01851.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02928.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1998.1244"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/0882824041310612"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2004.17.370"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.3.210"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/340505"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02582.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/322035"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.6.2944"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200010)62:2<267::AID-JMV20>3.0.CO;2-8"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02039.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200205000-00033"},{"key":"e_1_2_5_18_2","first-page":"2031","volume-title":"Nelson Textbook of Pediatrics","author":"Nicholson JF","year":"1996"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)01868-2"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2005.06.011"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118302"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01318.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/380908"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.10.8485-8495.1999"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3542"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.2037"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.2.1060"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.07.012"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3038.2006.00501.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3038.2006.00501.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:09:47Z","timestamp":1696921787000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3038.2006.00501.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,18]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1111\/j.1399-3038.2006.00501.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3038.2006.00501.x","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,18]]}}}