{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:04:53Z","timestamp":1759730693330},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T00:00:00Z","timestamp":1173225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>Elevated serum immunoglobulin E (IgE) and increased prevalence of atopy is reported in patients infected with human immunodeficiency virus (HIV). The elevated serum IgE may be attributed to polyclonal stimulation of B cells or IgE production against allergens, viruses, fungi and bacteria. This study investigates the prevalence of atopy in perinatally HIV\u2010infected children, and the relationships between serum IgE (and other serum immunoglobulins) with atopy, CD4+ cell count and HIV\u2010disease stage. Serum immunoglobulin levels, epicutaneous skin test for common aeroallergens, clinical Centers for Disease Control and Prevention (CDC) classification, CD4+ cell counts and allergy history were extracted from the charts of perinatally HIV\u2010infected children on highly active antiretroviral therapy. The prevalence of atopy (52%) and the pattern of aeroallergen sensitivity were comparable with the US pediatric population. Serum IgE levels did not correlate with clinical disease stage. However, in non\u2010atopic patients, serum IgE levels increased with disease progression (p\u2003=\u20030.02). There was an inverse relationship between the prevalence of elevated serum IgE levels and atopy with progression of disease (p\u2003=\u20030.019). Serum IgE did not correlate with atopy, CD4+ cell count, or duration of HIV infection or levels of serum immunoglobulins. This is the first study to show no increased prevalence of atopy in perinatally HIV\u2010infected children compared with the general population. In advanced stages of HIV, elevated serum IgE may be specific for antigens other than those known as allergens.<\/jats:p>","DOI":"10.1111\/j.1399-3038.2006.00522.x","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T18:07:04Z","timestamp":1173290824000},"page":"298-303","source":"Crossref","is-referenced-by-count":10,"title":["IgE and atopy in perinatally HIV\u2010infected children"],"prefix":"10.1111","volume":"18","author":[{"given":"Corinna S.","family":"Bowser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rauno O.","family":"Joks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cascy\u2010Arnoux","family":"Charlot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Jack Moallem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90154-V"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70177-5"},{"key":"e_1_2_6_4_2","first-page":"332","article-title":"IgE levels in pediatric HIV\u20101 infection","volume":"75","author":"Ellaurie M","year":"1995","journal-title":"Ann Allergy Asthma Immunol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80042-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199906000-00019"},{"key":"e_1_2_6_7_2","first-page":"57","article-title":"Hypersensitivity reactions to drugs in HIV\u2010infected patients. 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