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The aim of this study was to examine the relationship between RSV infection and expression of perforin and IFN\u2010<jats:italic>\u03b3<\/jats:italic> in CX<jats:sub>3<\/jats:sub>CR1\u2010expressing peripheral blood CD8<jats:sup>+<\/jats:sup> T cells. Samples were collected from infants with RSV bronchiolitis, both in the acute and convalescence phase (n\u2003=\u200312), and from their age\u2010 and sex\u2010matched healthy controls (n\u2003=\u200315). Perforin expression and IFN\u2010<jats:italic>\u03b3<\/jats:italic> secretion in CX<jats:sub>3<\/jats:sub>CR1<jats:sup>+<\/jats:sup> CD8<jats:sup>+<\/jats:sup> T cells were assessed by four\u2010color flow cytometry. The NF\u2010<jats:italic>\u03ba<\/jats:italic>B p50 and p65 subunit levels were also determined as markers of RSV\u2010induced inflammation. Study results showed perforin and CX<jats:sub>3<\/jats:sub>CR1 expression to be significantly lower in the convalescent phase of infected infants than in healthy controls. There was no significant difference in IFN\u2010<jats:italic>\u03b3<\/jats:italic> secretion and NF\u2010<jats:italic>\u03ba<\/jats:italic>B binding activity between two time\u2010points in RSV\u2010infected infants, or when compared with healthy controls. Infants with prolonged wheezing had lower acute\u2010phase CX<jats:sub>3<\/jats:sub>CR1 levels in peripheral blood. These data indicate existence of an event persisting after acute RSV infection that is able to modulate effector functions of cytotoxic T cells, and also link disease severity with CX<jats:sub>3<\/jats:sub>CR1 expression.<\/jats:p>","DOI":"10.1111\/j.1399-3038.2007.00611.x","type":"journal-article","created":{"date-parts":[[2008,2,2]],"date-time":"2008-02-02T04:38:27Z","timestamp":1201927107000},"page":"148-156","source":"Crossref","is-referenced-by-count":9,"title":["Expression of chemokine receptor CX<sub>3<\/sub>CR1 in infants with respiratory syncytial virus 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