{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:20:48Z","timestamp":1782138048173,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>To cite this article:<\/jats:bold> MacGinnitie A, Aloi F, Mishra S. Clinical characteristics of pediatric patients evaluated for primary immunodeficiency. <jats:italic>Pediatric Allergy Immunology<\/jats:italic> 2011; <jats:bold>22<\/jats:bold>: 671\u2013675.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:\u2002<\/jats:bold> When to evaluate a child for possible immune deficiency is a challenge, as many children have frequent infections for which they are treated with antibiotics. We aimed to describe the clinical characteristics of children evaluated for possible primary immunodeficiency in a specialist clinic. We specifically aimed to evaluate widely promulgated \u2018warning signs of primary immunodeficiency\u2019 and to evaluate the relationship between primary immunodeficiency and atopy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A retrospective analysis of 141 children who underwent testing for possible primary immunodeficiency was undertaken.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Thirty\u2010two (23%) children were diagnosed with an underlying primary immunodeficiency, and published warning signs were neither sensitive nor specific for primary immunodeficiency. Patients with allergy as determined by the presence of antigen\u2010specific IgE were more likely to be diagnosed with immunodeficiency.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Widely promulgated warning signs did not distinguish between patients with and without primary immunodeficiency. Likewise, primary immunodeficiency and allergy may coexist.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-3038.2011.01167.x","type":"journal-article","created":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T01:32:25Z","timestamp":1301535145000},"page":"671-675","source":"Crossref","is-referenced-by-count":39,"title":["Clinical characteristics of pediatric patients evaluated for primary immunodeficiency"],"prefix":"10.1111","volume":"22","author":[{"given":"Andrew","family":"MacGinnitie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Aloi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61142-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03432.x"},{"key":"e_1_2_5_4_2","volume-title":"Immunologic Disorders in Infants and Children","author":"Steihm ER","year":"2004"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60638-2"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.01.761"},{"key":"e_1_2_5_7_2","unstructured":"Jeffrey Modell Foundation[homepage on the Internet]. New York:Jeffrey Modell Foundation. Available at:http:\/\/www.jmfworld.org(accessed 9 December 2010).2009."},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.01.008"},{"key":"e_1_2_5_9_2","volume-title":"International Classification of Diseases","author":"World Health Organization","year":"2004"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026416017763"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2003.12.005"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012241117984"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992280003900406"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4725"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00445-1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.2.190"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.3.329-332.2006"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.050"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00259.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00228.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.037"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.044"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3038.2011.01167.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3038.2011.01167.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T13:32:29Z","timestamp":1697290349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3038.2011.01167.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,30]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1399-3038.2011.01167.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3038.2011.01167.x","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,30]]}}}