{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:57:52Z","timestamp":1781931472630,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T00:00:00Z","timestamp":1332288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>To cite this article:<\/jats:bold> Yazicioglu M, Elmas R, Turgut B, Genchallac T. The association between DRESS and the diminished numbers of peripheral B lymphocytes and natural killer cells. <jats:italic>Pediatr Allergy Immunol<\/jats:italic> 2012: <jats:bold>23<\/jats:bold>: 289\u2013296.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Drug reaction with eosinophilia and systemic symptoms (DRESS) is a drug\u2010induced, severe multiorgan system reaction whose exact pathogenesis remains unknown. This study aimed at evaluating specific changes in peripheral blood lymphocyte subtypes associated with DRESS during antibiotic treatment. We analyzed six patients with DRESS. A complete blood count and peripheral blood lymphocytes immunophenotyping were carried out at symptom onset and at follow\u2010up visits. Acute\u2010phase reactants and liver enzymes were measured in all patients. Other tests \u2013 viral serology, serum immunoglobulin levels, and skin tests were performed when possible. B\u2010cell counts were low in all patients at the onset of DRESS, and natural killer (NK) cells were low in all cases except one. During recovery, B\u2010cell numbers were within a normal range in five patients. In one, there was even a 10\u2010fold increase in B\u2010cell counts, although the level was mildly low after 3\u2003months. NK\u2010cell numbers were within a normal range in three patients. The mean numbers of B cells and NK cells were significantly higher in the second samples compared to the values on admission. Serum IgA and IgM levels were low in one patient. The drug provocation test was positive with cefotaxime in one patient. Viral serology, performed on five patients, was negative. A decrease in B\u2010cell and NK\u2010cell counts was the most consistent finding associated with the onset of antibiotic\u2010induced DRESS in our patients. 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