{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:05:28Z","timestamp":1775855128891,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>To cite this article:<\/jats:bold> Sverremark\u2010Ekstr\u00f6m E, Hultgren EH, Borres MP, Nilsson C. Peanut sensitization during the first 5\u2003yr of life is associated with elevated levels of peanut\u2010specific IgG. <jats:italic>Pediatr Allergy Immunol<\/jats:italic> 2012: <jats:bold>23<\/jats:bold>: 224\u2013229.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Allergen\u2010specific IgE antibodies are implicated in allergic diseases while allergen\u2010specific IgG antibodies have been proposed to prevent allergic reactions. The objective for this study was to study whether the immune response (IgG and IgG4) to peanut differs in IgE\u2010sensitized and non\u2010sensitized young children.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 239 children have been followed prospectively from birth to 5\u2003yr of age. The levels of IgG and IgG4 to peanut, Ara h 2, and Ara h 8 were analyzed at 2 and 5\u2003yr of age and related to IgE sensitization and peanut consumption.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The levels of peanut\u2010specific IgG and IgG4 were significantly higher in peanut\u2010sensitized children at 2 and 5\u2003yr of age when compared with non\u2010sensitized children and children sensitized to other food\/inhalant allergens. A strong correlation was seen between levels of peanut\u2010specific IgG\/IgG4\u2010ratios and peanut\u2010specific IgE at 5\u2003yr of age. Children avoiding peanuts, a subgroup of the peanut sensitized, had statistically significant higher levels of IgE to peanut and a tendency of higher IgG and IgG4 levels to peanut. In the avoidance group, significant correlations between IgE and IgG\/IgG4 to peanut were found compared with children eating peanuts.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Peanut\u2010specific IgG or IgG4 levels were elevated in peanut\u2010sensitized children especially those avoiding peanuts. In our study, IgG and IgG4 do not seem to indicate tolerance or protection from sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-3038.2012.01290.x","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T13:37:08Z","timestamp":1334669828000},"page":"224-229","source":"Crossref","is-referenced-by-count":17,"title":["Peanut sensitization during the first 5\u2003yr of life is associated with elevated levels of peanut\u2010specific IgG"],"prefix":"10.1111","volume":"23","author":[{"given":"E.","family":"Sverremark\u2010Ekstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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