{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:36:01Z","timestamp":1773153361490,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,9]],"date-time":"2012-09-09T00:00:00Z","timestamp":1347148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>To cite this article:<\/jats:bold> Dello Iacono I, Tripodi S, Calvani M, Panetta V, Verga MC, Miceli Sopo S. Specific oral tolerance induction with raw hen\u2019s egg in children with very severe egg allergy: A randomized controlled trial. <jats:italic>Pediatr Allergy Immunol<\/jats:italic> 2012: <jats:bold>00<\/jats:bold>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Treatment of severe egg allergy is avoidance of hen\u2019s egg (HE) and carrying self\u2010injectable epinephrine. Specific oral tolerance induction (SOTI) seems a promising alternative treatment. However, some aspects of SOTI are still considered experimental.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We evaluated the efficacy and safety of an original 6\u2010month SOTI protocol in children with very severe HE allergy using raw HE emulsion. Twenty children (age range: 5\u201311\u2003yr) were randomized equally into a SOTI treatment group and a control group. The treatment group started SOTI and underwent a second challenge 6\u2003months later. Control children were kept on an egg\u2010free diet for 6\u2003months and then underwent a second challenge.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> After 6\u2003months, 9\/10 children of the SOTI group (90%) achieved partial tolerance (at least 10\u2003ml, but &lt;40\u2003ml of raw HE emulsion, in a single dose) and 1 (10%) was able to tolerate only 5\u2003ml (no tolerance). After 6\u2003months, nine control children tested positive to the second challenge at a dose \u22640.9\u2003ml of raw HE emulsion, and one reacted to 1.8\u2003ml (SOTI vs. control group p\u2003&lt;\u20030.0001). All children in the SOTI group had side effects, but no child had a grade 5 reaction according to the Sampson grading.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Six months of SOTI with raw HE emulsion resulted in partial tolerance, with regular intake, in a significant percentage of children with severe egg allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-3038.2012.01349.x","type":"journal-article","created":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T02:19:11Z","timestamp":1347243551000},"page":"66-74","source":"Crossref","is-referenced-by-count":73,"title":["Specific oral tolerance induction with raw hen\u2019s egg in children with very severe egg allergy: A randomized controlled trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Iride","family":"Dello Iacono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Tripodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Calvani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Panetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmela","family":"Verga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Miceli Sopo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,9]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.4.e8"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.048"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70167-3"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.024"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00975.x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.9.649"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.040"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.08.028"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01468.x"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00542.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.027"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01196.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.016"},{"key":"e_1_2_9_15_2","first-page":"12","article-title":"Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. 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