{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:13:05Z","timestamp":1764688385211},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T00:00:00Z","timestamp":1085529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Liver transplantation (LT) is an established treatment for children with acute and chronic liver failure. Some reports suggest that infants under the age of 1\u2003yr and children weighing under 13\u2003kg are high\u2010risk groups associated with less satisfactory results. This report describes our experience during the pediatric intensive care unit stay of 16 infants weighing &lt;7\u2003kg who received LT. We reviewed the records of 16 infants with median age 7.4\u2003months and median weight 5.8\u2003kg, who received 18 liver allografts, nine whole and nine reduced. We also reviewed the use of adrenergic agonist agents, anti\u2010infectious agents, antihypertensive agents, diuretics, immunosuppression protocol, sedation\u2010analgesia agents, others agents (prostaglandin E<jats:sub>1<\/jats:sub>, heparin and dipyridamole), diagnosis and management of rejection episodes, follow\u2010up examination, nutrition and outcome. Mean peri\u2010operative blood transfusions were 204\u2003mL\/kg, 188\u2003mL\/kg of plasma and 36\u2003mL\/kg of platelets; mean operative time was 5\u2003h. Primary abdominal wound closure was possible in nine patients. Median initial intensive care unit stay was 18\u2003days. Reasons for an initial stay of more than 18\u2003days were retransplantation (1), gastrointestinal bleeding (2), paralytic ileus and atelectasis (2), septic shock (2), diaphragmatic paralysis, renal impairment and acute respiratory distress syndrome (2). Mean requirement for artificial ventilation was 168\u2003h. Mean use of dobutamine, prostaglandin E<jats:sub>1<\/jats:sub> and dopamine was 3.3, 7.5 and 8.8\u2003days, respectively. Parenteral nutrition was started at a mean of 48\u2003h and oral food intake was started at a mean of 72\u2003h. The most frequent complications were infection, atelectasis, gastrointestinal bleeding, acute renal failure and hepatic artery thrombosis. Four children required six re\u2010explorations and two received retransplantation. Mean overall survival rate was 82% and graft survival was 72%. Weight alone (under 7\u2003kg) should not be considered as a contraindication for LT. The survival rate of children post\u2010LT is excellent regardless of graft type.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2004.00128.x","type":"journal-article","created":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T13:12:13Z","timestamp":1085577133000},"page":"228-232","source":"Crossref","is-referenced-by-count":30,"title":["Liver transplantation in infants weighing under 7\u2003kilograms: Management and outcome of PICU"],"prefix":"10.1111","volume":"8","author":[{"given":"Juan","family":"Iglesias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas A.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Roqueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marino","family":"Asensio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Margarit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,26]]},"reference":[{"key":"e_1_2_25_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200711"},{"key":"e_1_2_25_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6908.825"},{"key":"e_1_2_25_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90612-6"},{"key":"e_1_2_25_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90653-X"},{"key":"e_1_2_25_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(93)90517-O"},{"key":"e_1_2_25_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90100-7"},{"key":"e_1_2_25_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200208000-00014"},{"key":"e_1_2_25_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.25763"},{"key":"e_1_2_25_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200207270-00006"},{"key":"e_1_2_25_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(93)90515-M"},{"key":"e_1_2_25_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(93)90516-N"},{"key":"e_1_2_25_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30242"},{"key":"e_1_2_25_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1999.98686"},{"key":"e_1_2_25_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.119989"},{"key":"e_1_2_25_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199809150-00010"},{"key":"e_1_2_25_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(97)82529-8"},{"key":"e_1_2_25_18_2","volume-title":"Yearbook of Intensive Care and Emergency Medicine","author":"Del Turco M","year":"2002"},{"key":"e_1_2_25_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80531-1"},{"key":"e_1_2_25_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80545-0"},{"key":"e_1_2_25_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199707270-00011"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2004.00128.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2004.00128.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T14:51:42Z","timestamp":1696949502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2004.00128.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,26]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1111\/j.1399-3046.2004.00128.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2004.00128.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,26]]}}}