{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:20:05Z","timestamp":1775503205041,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,8]],"date-time":"2004-09-08T00:00:00Z","timestamp":1094601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Improving survival rates following pediatric bone marrow transplantation (BMT) will likely result in greater numbers of children progressing to end\u2010stage renal disease (ESRD) because of prior chemotherapy, irradiation, sepsis, and exposure to nephrotoxic agents. Renal transplantation remains the treatment of choice for ESRD; however, the safety of renal transplantation in this unique population is not well established. We report our experience with living related renal transplantation in three pediatric patients with ESRD following prior BMT. Two patients with neuroblastoma and ESRD because of BMT nephropathy, and one patient with Schimke immuno\u2010osseous dysplasia and ESRD because of immune complex mediated glomerulonephritis and nephrotic syndrome. Age at time of BMT ranged from 2 to 7\u2003yr. All patients had stable bone marrow function prior to renal transplantation. Age at renal transplant ranged from 8 to 14\u2003yr. All three patients have been managed with conventional immunosuppression, as no patient received a kidney and BMT from the same donor source. These patients are currently 7\u2003months to 6\u2003yr status post\u2010living related transplant. All have functioning bone marrow and kidney transplants, with serum creatinine levels ranging 0.6\u20131.2\u2003mg\/dL. There have been no episodes of rejection. One patient with a history of grade III skin and grade IV gastrointestinal\u2010graft\u2010vs.\u2010host disease (GI\u2010GVHD) prior to transplantation, had a mild flare of GI\u2010GVHD (grade I) post\u2010renal transplant and is currently asymptomatic. The incidence of opportunistic infection has been comparable with our pediatric renal transplant population without prior BMT. One patient was treated for basal cell carcinoma via wide local excision. Renal transplantation is an excellent option for the treatment of pediatric patients with ESRD following BMT. Short\u2010term results in this small population show promising patient and graft survival, however long\u2010term follow\u2010up is needed. Pre\u2010existing immune system impairment and bone marrow function should be taken into consideration when weighing different immunosuppressive agents for renal transplantation. Patients who have undergone renal transplantation following BMT are at high risk for opportunistic infections and malignancy, and need life\u2010long medical surveillance.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2004.00208.x","type":"journal-article","created":{"date-parts":[[2004,9,8]],"date-time":"2004-09-08T13:51:34Z","timestamp":1094651494000},"page":"507-512","source":"Crossref","is-referenced-by-count":35,"title":["Successful renal transplantation following prior bone marrow transplantation in pediatric patients"],"prefix":"10.1111","volume":"8","author":[{"given":"Susan E.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond J.","family":"Hutchinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meelie","family":"DebRoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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