{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:02:23Z","timestamp":1772766143538,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold><jats:bold> Background:\u2002<\/jats:bold> Hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PPH) are pulmonary vascular disorders which occur in patients with severe liver disease and\/or portal hypertension. Although these syndromes are frequently diagnosed in patients undergoing assessment for liver transplantation, they seldom occur in the same patient.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> This report describes a female paediatric patient, born with extra\u2010hepatic biliary atresia, who required liver transplantation, at the age of 15, for secondary biliary cirrhosis. She had severe HPS prior to her first liver transplant, which resolved rapidly following surgery, as well as indirect evidence for PPH. She required a second liver transplant 1\u2003yr later for chronic rejection. Whilst evaluating the patient for a third liver transplant, 4\u2003yr later, severe PPH was discovered. The patient died 3\u2003months later from right heart failure.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> HPS and PPH may coexist however they may show differing responses to liver transplantation with progression of PPH despite the resolution of HPS.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2004.00221.x","type":"journal-article","created":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T16:27:10Z","timestamp":1106324830000},"page":"127-131","source":"Crossref","is-referenced-by-count":19,"title":["Development of hepatopulmonary syndrome and portopulmonary hypertension in a paediatric liver transplant patient"],"prefix":"10.1111","volume":"9","author":[{"given":"Tahir","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Isaac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Liver 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syndrome: Physiopathology of impaired gas exchange","volume":"16","author":"Robert V","year":"1999","journal-title":"Rev Mal Respir"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70302-6"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)91200-N"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50023"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2000.6356"},{"key":"e_1_2_7_22_2","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1182\/blood-2002-10-3289","article-title":"Late\u2010onset noninfectous pulmonary complications after allogeneic stem cell transplantation are significantly associated with chronic graft versus host disease and with the graft versus leukaemia effect","volume":"102","author":"Saikada 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