{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:44:16Z","timestamp":1791823456727,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T00:00:00Z","timestamp":1114041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Acute rejection leading to renal graft failure is more frequent among children. In patients treated with T cell antibody induction, retrospective data from the pediatric registry show a 22% reduction in the risk of graft failure. We conducted a randomized trial (n\u2003=\u2003287) using OKT3 mAbs in one (OKT3) arm and intravenous cyclosporine in the other arm (CYS). Maintenance therapy consisted of randomized, double blind Sandimmune<jats:sup>\u00ae<\/jats:sup> or Neoral<jats:sup>\u00ae<\/jats:sup> together with prednisone and either azathioprine (AZA) or mycophenolate mofetil (MMF). Morbidity, mortality, rejection rates and adverse reactions in the two study arms were similar. Through 4\u2003yr, graft failure was 27% in OKT3 and 19% in CYS (p\u2003=\u20030.15). One\u2010year graft survival was 89.1% in OKT3 and 89.2% in CYS (p\u2003=\u2003.19). In multivariate analysis, OKT3 had a numerically inferior graft survival (RR\u2003=\u20031.4, CI 0.8\u20132.2, p\u2003=\u20030.22). In OKT3 graft survival was inferior for children aged 6\u2003yr or younger. Our trial demonstrates that the incidence of acute rejection or graft failure in pediatric patients is not improved by OKT3 induction therapy relative to cyclosporine induction.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2005.00296.x","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T10:11:40Z","timestamp":1117188700000},"page":"282-292","source":"Crossref","is-referenced-by-count":32,"title":["A randomized multicenter trial of OKT3 mAbs induction compared with intravenous cyclosporine in pediatric renal transplantation"],"prefix":"10.1111","volume":"9","author":[{"given":"Mark R.","family":"Benfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Tejani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Harmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Stablein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The CCTPT study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2003.00029.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2000.00117.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2000.00116.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199002000-00019"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199402150-00011"},{"key":"e_1_2_7_7_2","first-page":"1755","article-title":"Uses of orthoclone OKT3 for prophylaxis of rejection and induction in initial nonfunction in kidney transplantation","volume":"22","author":"Kahana L","year":"1990","journal-title":"Transplant Proc"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199301000-00009"},{"key":"e_1_2_7_9_2","first-page":"680","article-title":"Glomerulonephritis induced by monoclonal anti\u2010Thy 1.1 antibodies. 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