{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:08:15Z","timestamp":1781683695938,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We describe here a patient with relapsed hepatoblastoma after LDLT who developed heart failure, which was treated with irinotecan hydrochloride (CPT\u201011). His native liver was replaced by a liver graft from his mother at 26\u2003months from the onset. However, LDLT failed to induce complete remission and he was diagnosed as relapsed hepatoblastoma six\u2003months after LDLT. We again administered cisplatin and doxorubicin. After six courses of chemotherapy, he developed congestive heart failure because of anthracycline toxicity. The chemotherapy regimen was therefore switched to irinotecan at 35\u2003mg\/m<jats:sup>2<\/jats:sup> daily for three\u2003days\/wk for two consecutive weeks, and repeated every 28\u2003days. After four courses of irinotecan, metastatic lesions were remarkably reduced in size, and the serum level of AFP decreased from 0.7\u2003million to 927\u2003ng\/mL. No severe side effects were documented and congestive heart failure improved. These results suggest that irinotecan may be safely given to a patient with relapsed hepatoblastoma after LDLT without serious side effects and may contribute to prolonging the survival.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2006.00517.x","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T08:33:44Z","timestamp":1152693224000},"page":"635-638","source":"Crossref","is-referenced-by-count":17,"title":["Response of heavily treated and relapsed hepatoblastoma in the transplanted liver to single\u2010agent therapy with irinotecan"],"prefix":"10.1111","volume":"10","author":[{"given":"Osamu","family":"Ijichi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Shinkoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Inomata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00095-6"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.22953"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199709000-00002"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10376"},{"key":"e_1_2_5_6_2","first-page":"32","article-title":"A phase I study of irinotecan in pediatric patients: A pediatric oncology group study","volume":"7","author":"Blaney S","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10300"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.22.3819"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.09.011"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20355"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/cncr.20846","article-title":"Five\u2010day courses of irinotecan as palliative therapy for patients with neuroblastoma","volume":"20","author":"Kushner BH","year":"2005","journal-title":"Cancer"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200202000-00007"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1002\/cncr.11308","article-title":"Effect of intrapatient dosage escalation of irinotecan on its pharmacokinetics in pediatric patients who have high\u2010grade gliomas and receive enzyme\u2010inducing anticonvulsant therapy","volume":"97","author":"Gajjar A","year":"2002","journal-title":"Cancer"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10266"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686188"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2006.00517.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2006.00517.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T09:19:27Z","timestamp":1697275167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2006.00517.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,12]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1399-3046.2006.00517.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2006.00517.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,12]]}}}