{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:32:43Z","timestamp":1791102763612,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,17]],"date-time":"2006-05-17T00:00:00Z","timestamp":1147824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Allogeneic hematopoietic stem cell transplantation represents the only curative option for malignant infantile osteopetrosis (MIOP), a rare disease of infants and young children, characterized by excessive accumulation of mineralized bone and abnormal hematopoiesis. We report a case of successful engraftment and stable full\u2010donor chimerism in a patient with MIOP who underwent unrelated donor cord blood transplantation (CBT). The donor was 2\u2010loci human leukocyte antigen (HLA)\u2010mismatch. After a conditioning regimen based on the combination of busulfan, cyclophosphamide, total body irradiation, and antithymocyte globulin, the patient received a dose of 3.85\u2003\u00d7\u200310<jats:sup>7<\/jats:sup>\/kg of nucleated cells. Neutrophil and platelet engraftment had been achieved by day +33 and +82, respectively, and the patient was discharged home on day +89. A successful engraftment of donor hematopoiesis was demonstrated and the child experienced grade II acute graft\u2010vs.\u2010host disease (GVHD) involving the skin only. A remarkable but non\u2010progressive decrease in lumbar spine bone mineral density was observed in the first nine months post\u2010transplant. This case suggests that unrelated donor CBT may be a feasible option in case of unavailability of a fully HLA\u2010matched related or unrelated donor.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2006.00537.x","type":"journal-article","created":{"date-parts":[[2006,5,17]],"date-time":"2006-05-17T08:46:22Z","timestamp":1147855582000},"page":"629-631","source":"Crossref","is-referenced-by-count":12,"title":["Successful unrelated mismatched cord blood transplantation in a child with malignant infantile osteopetrosis"],"prefix":"10.1111","volume":"10","author":[{"given":"Tang\u2010Her","family":"Jaing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Woei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Hsiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Anne","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Jan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010I","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,17]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1980","volume-title":"Nelson Textbook of Paediatrics","author":"Hall BD","year":"1996"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-004-0169-z"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.bmt.1704194","article-title":"Long\u2010term outcome of haematopoietic stem cell transplantation in autosomal recessive osteopetrosis: an EBMT report","volume":"32","author":"Driesseb GJ","year":"2003","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63798-4"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1056\/NEJMra040952","article-title":"Osteopetrosis","volume":"30","author":"Tolar J","year":"2004","journal-title":"N Engl J Med"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700946"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000179961.72889.bf"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2004.11.001"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-20040701-15"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199906000-00017"},{"key":"e_1_2_5_12_2","first-page":"1959","article-title":"A practical approach to hypercalcemia","volume":"67","author":"Carroll MF","year":"2003","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1034\/j.1399-3046.1999.00063.x","article-title":"Human malignant osteopetrosis: pathophysiology, management and the role of bone marrow transplantation","volume":"1","author":"Fasth A","year":"1999","journal-title":"Pediatr Transplant"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2006.00537.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2006.00537.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T09:19:40Z","timestamp":1697275180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2006.00537.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,17]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1399-3046.2006.00537.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2006.00537.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,17]]}}}