{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:46:51Z","timestamp":1761630411687},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,5,19]],"date-time":"2006-05-19T00:00:00Z","timestamp":1147996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Liver recipients who have antibodies to hepatitis B core antigen (anti\u2010HBc) or received an anti\u2010HBc positive liver graft are at risk of acquiring <jats:italic>de novo<\/jats:italic> hepatitis B infection so a life long prophylaxis is required. A post\u2010transplant vaccination against hepatitis B virus (HBV) can offer a better alternative than either hepatitis B hyperimmune globulin (HBIG) or lamivudine. This study investigated the course of anti\u2010HBs titer after vaccination and analyzed the factors that influence the response. Between October 1999 and February 2003, 37 pediatric patients were given a post\u2010transplant vaccination when an anti\u2010HBc positive graft was used, the recipient was anti\u2010HBc positive, or when anti\u2010HBs titer was below 20\u2003IU\/L irrespective of the serological status. Thirty\u2010three patients responded to the vaccine and did not require further HBIG injections at a mean follow up of 33.6\u2003months. Fifteen patients were good responder and only needed a single set of vaccines, and 18 were poor responder needing additional boosters. Two patients developed <jats:italic>de novo<\/jats:italic> hepatitis B infection and two required additional HBIG injections. Preoperative severity of liver disease, serological status of HBV of recipient or donor, use of HBIG or pulse steroid therapy, type of vaccines, and dose or time interval between doses had no influence on response rate. Recipients with a high preoperative anti\u2010HB titer, small graft\u2013recipient weight ratio (GRWR), greater catch up growth, heavier body weight, lower tacrolimus level at the time of vaccination, and longer time interval between transplant or steroid medication and vaccination yielded good response. If well tailored, post\u2010transplant vaccination can be effective and offer patients prophylaxis against <jats:italic>de novo<\/jats:italic> hepatitis B infection for a prolonged period of time.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2006.00540.x","type":"journal-article","created":{"date-parts":[[2006,5,19]],"date-time":"2006-05-19T08:43:40Z","timestamp":1148028220000},"page":"479-486","source":"Crossref","is-referenced-by-count":30,"title":["Long\u2010term protection against hepatitis B in pediatric liver recipients can be achieved effectively with vaccination after transplantation"],"prefix":"10.1111","volume":"10","author":[{"given":"Choon Hyuck David","family":"Kwon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Suk","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam\u2010Joon","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Hwan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Beom","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai\u2010Young","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoan Jong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Kee","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuhn 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