{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:20:05Z","timestamp":1767626405786,"version":"3.32.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T00:00:00Z","timestamp":1159833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>Bacterial infection remains a major problem after solid organ transplantation (SOT), especially in children. Piperacillin\u2013tazobactam (Pip\u2013Tazo) is a beta\u2010lactam\u2010antibiotic combination with a broad spectrum of activity including gram\u2010positive cocci as well as gram\u2010negative rods, non\u2010fermentative and anaerobic bacteria. The aim of this retrospective study was to critically review our experience with Pip\u2013Tazo as perioperative prophylactic agent in pediatric non\u2010renal SOT. Between 1993 and 2003 Pip\u2013Tazo was used as initial perioperative prophylaxis in 45 pediatric patients who underwent a total of 49 transplants (36 liver\u2010, seven cardiac\u2010, two lung\u2010, and four small bowel\u2010) at our department. Median age of the children was 7.9 (range 0.5\u201318.1) years. A total of 34 rejection episodes following 27 transplants were diagnosed. During first hospitalization 44 infectious episodes were observed. Bacteria were responsible for 22 episodes including sepsis (n\u2003=\u200310), pneumonia (n\u2003=\u20035), wound infection (n\u2003=\u20034), urinary tract infection (n\u2003=\u20031), and clostridial colitis (n\u2003=\u20032). The isolated organisms were gram\u2010positive cocci (n\u2003=\u200312), gram\u2010negative rods (n\u2003=\u20033), non\u2010fermentative bacilli (n\u2003=\u20034), and anaerobes (n\u2003=\u20033). Ten episodes were caused by Pip\u2013Tazo resistant bacteria. Twenty\u2010one of these infections were observed following antirejection therapy with pulse steroids. At later time points nine infectious episodes were successfully treated with a second course of Pip\u2013Tazo. During follow up, eight patients died. Six deceased perioperatively: five from infection including aspergillosis (n\u2003=\u20034) and<jats:italic>Pneumocystis jiroveci<\/jats:italic>pneumonia (n\u2003=\u20031) and cerebrovascular bleeding (n\u2003=\u20031) and two children later on. At present 37 children (82%) are alive with well functioning graft after a median follow up of 39.2 (range 0.6\u2013123.5) months. No severe side effects caused by Pip\u2013Tazo were observed in any of the children. Pip\u2013Tazo may be a suitable single agent for perioperative prophylaxis in pediatric non\u2010renal solid organs recipients, however, a prospective comparative study is needed to make final conclusions.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2006.00605.x","type":"journal-article","created":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T16:42:20Z","timestamp":1159893740000},"page":"38-48","source":"Crossref","is-referenced-by-count":10,"title":["Experience with the use of piperacillin\u2013tazobactam in pediatric non\u2010renal solid organ 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