{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:53:28Z","timestamp":1789847608975,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,31]],"date-time":"2007-03-31T00:00:00Z","timestamp":1175299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We present an infant with cDGS overlapping with CHARGE syndrome, who suffered from T\u2010cell deficiency treated with screened healthy DLI from an unrelated donor (8\/10 match). The first dose of DLI (1.1\u2003\u00d7\u200310<jats:sup>6<\/jats:sup> CD3+\/kg) was administered at the age of six months, the second one (0.9\u2003\u00d7\u200310<jats:sup>6<\/jats:sup> CD3+\/kg) 36\u2003days later. No conditioning was employed, GvHD prophylaxis consisting of CsA was used only during the second infusion. Since day+10 after the first DLI, split chimerism showing T\u2010cell engraftment has been documented. Proliferative response to PHA was detected on day+145. The treatment was complicated by severe acute GvHD (grade II\u2010III) after the first DLI and prolonged chronic liver cholestatic GvHD developing after the second DLI. Vigorous EBV proliferation four\u2003wk after the second DLI was accompanied by peripheral expansion of CD8+ donor cells. The patient, 26\u2010months old, is clinically well and has slowly started to gain his developmental milestones. We believe that infusions of small doses of DLI from an unrelated donor represent a potentially helpful therapeutic option in patients with cDGS\/CHARGE phenotype.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2007.00702.x","type":"journal-article","created":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T22:35:52Z","timestamp":1176935752000},"page":"441-447","source":"Crossref","is-referenced-by-count":28,"title":["Unrelated partially matched lymphocyte infusions in a patient with complete DiGeorge\/CHARGE 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