{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:03:06Z","timestamp":1760043786675},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T00:00:00Z","timestamp":1176336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> PTLD represent major post\u2010transplant complications. The major etiologic factor is EBV. Association with cold agglutinin disease has not been described so far. We report a three\u2010yr\u2010old girl who developed oligoclonal EBV\u2010negative plasmacytic hyperplasia as well as Coombs test\u2010positive anemia one\u2003yr after multivisceral organ transplantation, performed after subtotal bowel resection for colointestinal aganglionosis and liver cirrhosis resulting from long\u2010term parenteral nutrition. The patient was treated for plasmacytic hyperplasia with cyclophosphamide and prednisolone and achieved clinical remission. One\u2003yr later PTLD progressed possibly driven by EBV to DLBCL. The migration patterns of the amplified Ig heavy chain genes demonstrated a probable clonal relationship of the DLBCL to a clone almost present in the plasmacytic hyperplasia. This progression was accompanied by a rapid rise of cold agglutinin titers with symptoms of severe cold agglutinin disease, leading to right femoral and extern iliac vein thromboses requiring partial leg amputation. After four cycles of rituximab, cyclophosphamide, and prednisolone, the patient achieved complete PTLD remission and the cold agglutinins disappeared. Summarizing, PTLD may be accompanied by cold agglutinin disease, and both may be successfully treated by immuno\u2010chemotherapy. The appearance of cold agglutinins in transplant patients may indicate PTLD development.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2007.00711.x","type":"journal-article","created":{"date-parts":[[2007,4,29]],"date-time":"2007-04-29T16:35:03Z","timestamp":1177864503000},"page":"547-551","source":"Crossref","is-referenced-by-count":17,"title":["Severe cold agglutinin disease caused by recurrent monomorphic Epstein\u2013Barr virus (EBV)\u2010associated post\u2010transplant lymphoproliferative disorder (PTLD), clonally related to an EBV\u2010negative plasmacytic hyperplasia in a pediatric multivisceral organ transplant recipient"],"prefix":"10.1111","volume":"11","author":[{"given":"Barbara","family":"Brunner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Kropshofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Ellemunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimund","family":"Margreiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandar","family":"Tzankov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,12]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"264","volume-title":"Tumours of Haematopoietic and Lymphoid Tissues","author":"Harris NL","year":"2001"},{"key":"e_1_2_6_3_2","unstructured":"NalesnikMA DemetrisAJ FungJJ RandhawaP ZeeviA.http:\/\/www.medscape.com\/viewprogram\/324accessed 15 December 2000."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.6.2052"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00318.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.53.5.238"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2002.02029.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2001.003002088.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.1999.00066.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.12.124"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.074"},{"key":"e_1_2_6_12_2","first-page":"3945","article-title":"A pilot study of chemoimmunotherapy (cyclophosphamide, prednisone, and rituximab) in patients with post\u2010transplant lymphoproliferative disorder following solid organ transplantation","volume":"9","author":"Orjuela M","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00037-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05426.x"},{"key":"e_1_2_6_15_2","first-page":"831","article-title":"Severe systemic autoimmune disease associated with Epstein\u2013Barr virus infection","volume":"26","author":"Sevilla J","year":"2004","journal-title":"J Pediatr Hematol Oncol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3597"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(02)03816-2"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2003.00080.x"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2007.00711.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2007.00711.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T21:25:51Z","timestamp":1696886751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2007.00711.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,12]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1399-3046.2007.00711.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2007.00711.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,12]]}}}