{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:13:43Z","timestamp":1760548423558},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,10]],"date-time":"2007-05-10T00:00:00Z","timestamp":1178755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Developments in surgical technique, immunosuppression, organ procurement and preservation, and patient selection criteria have resulted in improved long\u2010term patient and graft survival after pediatric liver transplantation. In this study, we examined the results of 196 liver transplants performed in 155 pediatric patients at University of Wisconsin Children\u2019s Hospital. Patients were divided into two groups according to age at the time of liver transplant. Infants under 12\u2003months of age comprised Group 1 (n\u2003=\u200374) and children from one to 18\u2003yr comprised Group 2 (n\u2003=\u2003122). Outcomes for whole, reduced\u2010size, and split liver transplantation were compared in infants and children. Biliary atresia was the most common indication in both groups. Patients underwent 128 whole size, 50 reduced size, and 18 split liver transplants. Forty\u2010one retransplantations were performed in 14 infants (18.9%) and in 27 children (22.1%). One hundred eleven patients (56.6%) had one or more rejection episode [37 infants (50.0%) and 74 children (60.6%)]. Thirty\u2010nine patients (19.8%) developed CMV infections, 42 (21.4%) developed EBV infections, and 14 developed PTLD (six infants and eight children). Thirty\u2010six patients (18.3%) developed HAT. Seven patients (4.5%) developed malignancy (one infant and six children). Out of 155 patients, 33 (21.3%) died during the study period. The most common etiology of mortality included central nervous system pathology (n\u2003=\u20037; 4.5%), sepsis (n\u2003=\u20036; 3.8%), and cardiac causes (n\u2003=\u20036; 3.8%). One\u2010, five\u2010, and 10\u2010yr actuarial patient survival was 86, 79, and 74% in infants and 90, 83 and 80% in children. Graft survival at one, five, and 10\u2003yr was 77, 73 and 71% in infants and 88, 81 and 78% in children, respectively. Despite its technical challenges, the outcomes of liver transplantation in pediatric patients with end\u2010stage liver disease are excellent and result in significant long\u2010term patient and graft survival.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2007.00737.x","type":"journal-article","created":{"date-parts":[[2007,5,10]],"date-time":"2007-05-10T19:57:07Z","timestamp":1178827027000},"page":"661-670","source":"Crossref","is-referenced-by-count":53,"title":["Liver transplantation in pediatric patients: Twenty years of experience at the University of Wisconsin"],"prefix":"10.1111","volume":"11","author":[{"given":"A. M.","family":"D\u2019Alessandro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Knechtle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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