{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:29:47Z","timestamp":1782602987994,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,9,15]],"date-time":"2007-09-15T00:00:00Z","timestamp":1189814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Anemia is a common finding in post\u2010liver transplant patients. Causes for the anemia include nutritional deficiencies, red cell aplasia as well as immune\u2010mediated hemolysis. One of the immunologic causes of hemolytic anemia is drug\u2010induced hemolysis. Tacrolimus is a common immunosuppressant used in post\u2010liver transplant patients to prevent graft rejection. There have been reports of tacrolimus\u2010associated hemolytic anemia secondary to hemolytic uremic syndrome as well as autoimmune hemolysis. There are also case\u2010reports of severe hemolytic anemia related to cold agglutinin production in post\u2010liver transplant patients. We described in this paper three cases of severe cold agglutinin hemolytic anemia in three pediatric liver transplant patients. Steroid therapy, plasmapheresis and withdrawal of tacrolimus led to resolution of the severe hemolytic process in each case. Whether the immune\u2010mediated hemolysis is related to tacrolimus is not clear and needs to be characterized further.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2007.00795.x","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T07:18:52Z","timestamp":1190099932000},"page":"931-936","source":"Crossref","is-referenced-by-count":18,"title":["Cold agglutinin syndrome in pediatric liver transplant recipients"],"prefix":"10.1111","volume":"11","author":[{"given":"Wendy","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Merker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Berquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurene","family":"Viele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil","family":"Glader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali J.","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200011270-00011"},{"key":"e_1_2_5_3_2","first-page":"4595","article-title":"Hemolysis in ABO\u2010incompatible liver transplantation","volume":"19","author":"Angstadt J","year":"1987","journal-title":"Transplant Proc"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005950050242"},{"key":"e_1_2_5_5_2","first-page":"282","article-title":"Tacrolimus\u2010related posttransplant lymphoproliferative disorder presenting as autoimmune hemolytic anemia","volume":"120","author":"DiGiuseppe JA","year":"1996","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199608)52:4<310::AID-AJH11>3.0.CO;2-H"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2000.140314.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(02)03816-2"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00460.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-08559-8.50007-8"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199803000-00012"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200310000-00022"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410273311702"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00636.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199801000-00016"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00774-7"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.02.024"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10062"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06573-4"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2007.00795.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2007.00795.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:10:51Z","timestamp":1696889451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2007.00795.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,15]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1399-3046.2007.00795.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2007.00795.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,15]]}}}