{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T08:25:02Z","timestamp":1746692702456},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T00:00:00Z","timestamp":1194912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We describe a six\u2010yr\u2010old boy who exhibited typical signs and symptoms of LCH with EBV\u2010associated hemophagocytic syndrome from the age of 15\u2003months. Multiple courses of conventional chemotherapy achieved only marginal improvement over the ensuring five\u2003yr. During this period, this boy experienced recurrent episodes of hemophagocytic syndrome associated with CMV infection. Five\u2003yr after the first diagnosis of LCH, the patient was treated with allogeneic PBSCT from his HLA\u2010identical eight\u2010yr\u2010old brother. PBSCT was performed using a TBI\u2010incorporating conditioning regimen comprising TBI, busulfan, and cyclophosphamide. Diabetes insipidus, typically a permanent consequence of LCH, was well controlled by DDAVP therapy. At the time of writing, this boy is alive and well, and had been disease\u2010free for more than two\u2003yr after the PBSCT.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2007.00834.x","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T01:24:06Z","timestamp":1195176246000},"page":"99-104","source":"Crossref","is-referenced-by-count":7,"title":["Successful treatment of refractory Langerhans cell histiocytosis by allogeneic peripheral blood stem cell transplantation"],"prefix":"10.1111","volume":"12","author":[{"given":"Chi\u2010Chieh","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Nan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,3]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"S41","article-title":"Treatment of Langerhans cell histiocytosis\u2010evolution and current approaches","volume":"23","author":"Ladisch S","year":"1994","journal-title":"Br J Cancer"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200112000-00018"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704065"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10024001-0159-2"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703193161207"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900715)66:2<284::AID-CNCR2820660215>3.0.CO;2-O"},{"key":"e_1_2_5_9_2","first-page":"39","article-title":"Marrow transplantation for treatment of multisystem progressive Langerhans cell histiocytosis","volume":"10","author":"Gerinix HT","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_10_2","first-page":"208","article-title":"Histiocytosis syndromes in children","volume":"1","author":"Writing Group of the Histiocyte Society","year":"1987","journal-title":"Lancet"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1178"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704056"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705015"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.10.2900"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00335.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.00573.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.2.433"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.3.806"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101183440303"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702875"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.7.1940.1940"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2007.00834.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2007.00834.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:17:33Z","timestamp":1697293053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2007.00834.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,3]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1399-3046.2007.00834.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2007.00834.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,3]]}}}