{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:48:06Z","timestamp":1761630486162},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Acute rejection episodes following pediatric renal transplantation have been progressively reduced by recent immunosuppressive regimens. Nevertheless, grafts continue to fail over time and surrogate parameters for long\u2010term RGS are lacking. We investigated post\u2010transplant renal function within the first yr as an independent predictor of long\u2010term RGS in 104 pediatric first kidney transplant recipients (mean age 11.1\u2003\u00b1\u20033.9\u2003yr; mean follow\u2010up 8.3\u2003\u00b1\u20033.5\u2003yr) transplanted between January 1989 and December 2000. GFR was assessed by use of the Schwartz formula at 30\u2003days and six and 12 months after transplantation, respectively. Patients were further stratified at all times according to GFR: (i) GFR&lt;45\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup>, (ii) GFR 45\u201380\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup>, and (iii) GFR&gt;80\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup>. Cox regression analysis including factors potentially influencing long\u2010term RGS, e.g., age, gender, transplant yr, HLA\u2010mismatch, underlying renal disease, clinical acute rejection, absolute GFR as well as the change in GFR within the first yr was performed. Graft failure occurred in 24 out of 104 patients (23%) 6.2\u2003yr (mean) after transplantation corresponding to a cumulative five\u2010yr graft survival of 87.5%. GFRs at 30\u2003days and six and 12 months were significantly associated with long\u2010term RGS in the univariate cox regression analysis (GFR at 30\u2003days, p\u2003=\u20030.045; GFR at six months, p\u2003=\u20030.004; GFR at 12\u2003months, p\u2003&lt;\u20030.001). None of the other variables were significant parameters of correlation. Multivariate cox analysis revealed a GFR below 45\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup> at 12\u2003months after transplantation as the only independent predictor of long\u2010term RGS (hazard ratio 55.9, 95% CI 5.29\u2013591, p\u2003=\u20030.001). GFR at 12 months post\u2010transplant is an excellent surrogate parameter for long\u2010term RGS in children. This parameter might be useful as a primary end\u2010point in short\u2010term pediatric clinical trials.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2008.00976.x","type":"journal-article","created":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T02:36:12Z","timestamp":1212633372000},"page":"365-370","source":"Crossref","is-referenced-by-count":18,"title":["Estimated one\u2010yr glomerular filtration rate is an excellent predictor of long\u2010term graft survival in pediatric first kidney transplants"],"prefix":"10.1111","volume":"13","author":[{"given":"Jutta","family":"Muscheites","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Wigger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdmute","family":"Drueckler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilka","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Wygoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar\u2010Christiane","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenther","family":"Kundt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Misselwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk\u2010E","family":"M\u00fcller\u2010Wiefel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Haffner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031643"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.1999.00011.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00805.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2001.010111.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.00003.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00356.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00704.x"},{"key":"e_1_2_6_9_2","first-page":"72","article-title":"Time\u2010dependent 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