{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:20:30Z","timestamp":1789518030488,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> In pediatric kidney transplantation, the effect of inadequate nephron dosing on graft survival remains undetermined. The aim of this study was to assess the use of D\/R BSA, as a reliable indicator of adequate nephron dosing, and eventually a tool to optimize pediatric graft allocation. Following Institutional Review Board approval, we reviewed deceased donor pediatric kidney transplantation (N\u2003=\u2003156). We divided patients into three groups, based on D\/R BSA: A \u22640.8; B 0.81\u20131.19; C \u22651.2. Five\u2010yr graft survival rates in the groups were: A 82.0%; B 94.9%; C 97.1% (p<jats:italic>\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.01). Group C had the lowest rate of acute rejection, suggesting a protective effect of increased D\/R BSA (group A\u2003=\u200335.7%, group B\u2003=\u200338.9%, group C\u2003=\u200318.8%; p<jats:italic>\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.029). The logistic regression analysis showed that decreased D\/R BSA ratio is a risk factor for loss of graft function, at one and five yr [i.e., group A OR 6 (95% CI 1.14\u201339.30, p<jats:italic>\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.015) and OR 4.49 (95% CI 1.46\u201313.79, p\u2003=\u20030.009), respectively]. We conclude that for pediatric recipients, D\/R BSA is a valuable adjunct when determining long\u2010term graft survival. Its utility may avoid an alloimmune\u2010independent risk factor, increasing the long\u2010term protective value of a good matching policy.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2008.01034.x","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T07:12:22Z","timestamp":1227683542000},"page":"290-299","source":"Crossref","is-referenced-by-count":24,"title":["The effect of donor\/recipient body surface area ratio on outcomes in pediatric kidney transplantation"],"prefix":"10.1111","volume":"13","author":[{"given":"Stefano","family":"Giuliani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Giorgio","family":"Gamba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikunj 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