{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:35:36Z","timestamp":1774366536643,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T00:00:00Z","timestamp":1268006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\u00c7eltik C, \u00dcn\u00fcvar A, Aydo\u011fan A, G\u00f6k\u00e7e S, \u00d6zt\u00fcrk G, G\u00fcll\u00fco\u011flu M, Y\u0131lmaz G, T\u00fcrko\u011flu S, Anak S, S\u00f6k\u00fcc\u00fc S, Durmaz \u00d6. Human herpes virus type 8\u2010associated Kaposi sarcoma in a pediatric liver transplant recipient.\u2028Pediatr Transplantation 2011: 15: E100\u2013E104. \u00a9 2010 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold>Development of KS in pediatric liver transplant recipients is a rare entity and has dismal prognosis. Latent HHV\u20108 infection, immunosuppression, and genetic predisposition are possible etiological factors. Decreasing the dose or cessation of immunosuppressive drugs, switching to sirolimus with antiproliferative and antitumor properties, and different chemotherapeutic regimens are the current therapeutic strategies. We herein report a pediatric liver transplant recipient who developed generalized KS at post\u2010transplant fifth month. The disease had an aggressive course despite the highly toxic chemotherapy. On the other hand, a prompt and durable response was provided by paclitaxel with tolerable side effects. The patient is now free of disease for at least 24\u2003months and healthy with good graft function under sirolimus therapy as maintenance immunosuppression. Instead of highly toxic chemotherapy, paclitaxel can be used as therapeutic option in cases with generalized disease and in those who are unresponsive to conventional chemotherapy. However, new studies are needed to assess the efficacy of the paclitaxel therapy in KS in the liver transplant recipients.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2010.01302.x","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T01:25:55Z","timestamp":1268097955000},"source":"Crossref","is-referenced-by-count":11,"title":["Human herpes virus type 8\u2010associated Kaposi sarcoma in a pediatric liver transplant 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